Recent Development of c-myc G-Quadruplex Ligands

Victor Pui-Yan Ma, Ka-Ho Leung, Daniel Shiu-Hin Chan, Wan-Chi Lam, Chung-Hang Leung, Dik Lung Ma

Research output: Contribution to journalJournal article


In this review, we summarize recent findings in the development of c-myc G-quadruplex ligands. Several features such as expanded aromatic rings, flexible molecules, dinuclear metal complexes, oligomers and G-quartet based ligands have been demonstrated to be advantageous for providing higher selectivity towards the c-myc G-quadruplex over duplex structures. High throughput screening methods including competition dialysis, G4 FID, FRET-based melting assay, direct ELISA and in silico virtual screening for analyzing the interaction between the ligands and the c-myc G-quadruplex are discussed. In particular, in silico virtual screening has been demonstrated to be a valuable means for the discovery of selective G-quadruplex ligands. Using this approach, ligands selective for the c-myc G-quadruplex have been successfully identified
Original languageEnglish
Pages (from-to)120-128
Number of pages9
JournalInternational Review of Biophysical Chemistry
Issue number4
Publication statusPublished - Aug 2011

User-Defined Keywords

  • c-myc G-quadruplex
  • G-quadruplex Ligands
  • High Throughput
  • Virtual Screening


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