Recent Advances on Transition-Metal-Catalyzed Asymmetric C‒H Arylation Reactions

Mingliang Li, Jun Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Transition-metal-catalyzed asymmetric C–H functionalization has become a powerful strategy to synthesize complex chiral molecules. Recently, catalytic enantioselective C–H arylation has attracted great interest from organic chemists to construct aryl-substituted chiral compounds. In this short review, we highlight recent advances in asymmetric C–H arylation from 2019 to late 2021, including enantioselective C(sp2)–H arylation to construct axial or planar chiral compounds, and enantioselective C(sp3)–H arylation to introduce central chirality via desymmetrization of the methyl group or methylene C–H activation. These processes proceed with palladium, rhodium, iridium, nickel, or copper catalysts, and utilize aryl halides, boron, or diazo derivatives as arylation reagents.

Original languageEnglish
Pages (from-to)4734-4752
Number of pages19
JournalSynthesis
Volume54
Issue number21
Early online date14 Dec 2021
DOIs
Publication statusPublished - Nov 2022

Scopus Subject Areas

  • Catalysis
  • Organic Chemistry

User-Defined Keywords

  • aryl­ation
  • asymmetric C-H activation
  • C(sp )-H arylation
  • C-H bond functionalization
  • chiral ligands
  • transition-metal catalysis

Fingerprint

Dive into the research topics of 'Recent Advances on Transition-Metal-Catalyzed Asymmetric C‒H Arylation Reactions'. Together they form a unique fingerprint.

Cite this