Recent Advances on Transition-Metal-Catalyzed Asymmetric C‒H Arylation Reactions

Transition metal-catalyzed direct asymmetric C−H functionalization has become a powerful strategy to synthesize complex chiral molecules. Recently, catalytic enantioselective C−H arylation has attracted great interest from organic chemists to construct aryl-substituted chiral compounds. In this short review, we intend to highlight the recent advancements in asymmetric C−H arylation from 2019 to now, including enantioselective C(sp2)−H arylation to construct axial or planar chiral compounds, and enantioselective C(sp3)−H arylation to introduce central chirality via desymmetrization of methyl group or direct methylene C–H activation. These processes proceed with palladium, rhodium, iridium, nickel or copper catalyst, and utilize aryl halides, boron or diazo derivatives as arylation reagents.