Recent advances in research of natural and synthetic bioactive quinolines

Po Yee Chung; Zhaoxiang Bian; Ho Yuen Pun; Dessy Chan; Albert Sun Chi Chan; Chung Hin Chui; Johnny Cheuk On Tang; Kim Hung Lam

doi:10.4155/fmc.15.34

Recent advances in research of natural and synthetic bioactive quinolines

Po Yee Chung, Zhaoxiang Bian, Ho Yuen Pun, Dessy Chan, Albert Sun Chi Chan, Chung Hin Chui, Johnny Cheuk On Tang, Kim Hung Lam^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

133 Citations (Scopus)

Abstract

Many natural products that consist of quinoline core are found to be bioactive and the versatility of quinoline and its derivatives have attracted great attention in the field of drug development. As a result, in recent years, many green and sustainable synthetic approaches for the synthesis of structurally diverse quinolines have been developed. This review covers four main aspects, namely bioactive quinoline alkaloids, the biological activity and mechanism of action of quinoline-based compounds as well as various quinoline syntheses.

Original language	English
Pages (from-to)	947-967
Number of pages	21
Journal	Future Medicinal Chemistry
Volume	7
Issue number	7
DOIs	https://doi.org/10.4155/fmc.15.34
Publication status	Published - 1 Jun 2015

Scopus Subject Areas

Molecular Medicine
Pharmacology
Drug Discovery

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abstract = "Many natural products that consist of quinoline core are found to be bioactive and the versatility of quinoline and its derivatives have attracted great attention in the field of drug development. As a result, in recent years, many green and sustainable synthetic approaches for the synthesis of structurally diverse quinolines have been developed. This review covers four main aspects, namely bioactive quinoline alkaloids, the biological activity and mechanism of action of quinoline-based compounds as well as various quinoline syntheses.",

author = "Chung, {Po Yee} and Zhaoxiang Bian and Pun, {Ho Yuen} and Dessy Chan and Chan, {Albert Sun Chi} and Chui, {Chung Hin} and Tang, {Johnny Cheuk On} and Lam, {Kim Hung}",

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AU - Chui, Chung Hin

AU - Tang, Johnny Cheuk On

AU - Lam, Kim Hung

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AB - Many natural products that consist of quinoline core are found to be bioactive and the versatility of quinoline and its derivatives have attracted great attention in the field of drug development. As a result, in recent years, many green and sustainable synthetic approaches for the synthesis of structurally diverse quinolines have been developed. This review covers four main aspects, namely bioactive quinoline alkaloids, the biological activity and mechanism of action of quinoline-based compounds as well as various quinoline syntheses.

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Recent advances in research of natural and synthetic bioactive quinolines

Abstract

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