Recent advances in research of natural and synthetic bioactive quinolines

Po Yee Chung, Zhaoxiang BIAN, Ho Yuen Pun, Dessy Chan, Albert Sun Chi Chan, Chung Hin CHUI, Johnny Cheuk On Tang, Kim Hung Lam*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

82 Citations (Scopus)

Abstract

Many natural products that consist of quinoline core are found to be bioactive and the versatility of quinoline and its derivatives have attracted great attention in the field of drug development. As a result, in recent years, many green and sustainable synthetic approaches for the synthesis of structurally diverse quinolines have been developed. This review covers four main aspects, namely bioactive quinoline alkaloids, the biological activity and mechanism of action of quinoline-based compounds as well as various quinoline syntheses.

Original languageEnglish
Pages (from-to)947-967
Number of pages21
JournalFuture Medicinal Chemistry
Volume7
Issue number7
DOIs
Publication statusPublished - 1 Jun 2015

Scopus Subject Areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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