Recent Advances in gem-Difluoroalkenes and Difluroenoxysilanes for Asymmetric Synthesis

Organofluorine compounds have consistently played a pivotal role in chemical synthesis, materials development, and drug discovery. Among these, chiral organofluorine compounds have emerged as a significant focus of research. Gem-difluoroalkenes and difluoroenoxysilanes, owing to their high reactivity and modifiability, are extensively employed in the synthesis of chiral organofluorine compounds. This review summarizes recent research progress in the use of these molecules in asymmetric synthesis. Their application in synthesizing biologically active chiral molecules could open new possibilities and lead to unexpected breakthroughs in medicinal chemistry.