Recent advances in developing small molecules targeting nucleic acid

Maolin Wang, Yuanyuan Yu, Chao Liang, Aiping Lyu, Ge Zhang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Citations (Scopus)
21 Downloads (Pure)


Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have been reported, providing basic information for nucleic acid drug discovery. This review focuses on the discovery and development of small molecules targeting nucleic acids.

Original languageEnglish
Article number779
JournalInternational Journal of Molecular Sciences
Issue number6
Publication statusPublished - 30 May 2016

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • DNA drug discovery
  • Nucleic acids
  • Nucleic acids targeting
  • RNA drug discovery
  • Small molecules


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