TY - JOUR
T1 - Receiving three doses of inactivated or mRNA COVID-19 vaccines was associated with lower odds of long COVID symptoms among people with a history of SARS-CoV-2 infection in Hong Kong, China
T2 - a cross-sectional survey study
AU - Zheng, Chen
AU - Yu, Fuk-Yuen
AU - Chan, Paul Shing-Fong
AU - Sun, Fenghua
AU - Chen, Xiang-Ke
AU - Huang, Wendy Ya-Jun
AU - Wong, Heung-Sang Stephen
AU - Fang, Yuan
AU - Wang, Zixin
N1 - This work was supported by the Research Grants Council (RGC) General Research Fund (GRF), Hong Kong [14608521]; and University Grants Committee, The Chinese University of Hong Kong, Hong Kong [3110155].
Publisher Copyright:
© The Author(s), 2024
PY - 2024/12/11
Y1 - 2024/12/11
N2 - High prevalence of long COVID symptoms has emerged as a significant public health concern. This study investigated the associations between three doses of COVID-19 vaccines and the presence of any and ≥3 types of long COVID symptoms among people with a history of SARS-CoV-2 infection in Hong Kong, China. This is a secondary analysis of a cross-sectional online survey among Hong Kong adult residents conducted between June and August 2022. This analysis was based on a sub-sample of 1,542 participants with confirmed SARS-CoV-2 infection during the fifth wave of COVID-19 outbreak in Hong Kong (December 2021 to April 2022). Among the participants, 40.9% and 16.1% self-reported having any and ≥3 types of long COVID symptoms, respectively. After adjusting for significant variables related to sociodemographic characteristics, health conditions and lifestyles, and SARS-CoV-2 infection, receiving at least three doses of COVID-19 vaccines was associated with lower odds of reporting any long COVID symptoms comparing to receiving two doses (adjusted odds ratio [AOR]: 0.69, 95% CI: 0.54, 0.87,
P = .002). Three doses of inactivated and mRNA vaccines had similar protective effects against long COVID symptoms. It is important to strengthen the coverage of COVID-19 vaccination booster doses, even in the post-pandemic era.
AB - High prevalence of long COVID symptoms has emerged as a significant public health concern. This study investigated the associations between three doses of COVID-19 vaccines and the presence of any and ≥3 types of long COVID symptoms among people with a history of SARS-CoV-2 infection in Hong Kong, China. This is a secondary analysis of a cross-sectional online survey among Hong Kong adult residents conducted between June and August 2022. This analysis was based on a sub-sample of 1,542 participants with confirmed SARS-CoV-2 infection during the fifth wave of COVID-19 outbreak in Hong Kong (December 2021 to April 2022). Among the participants, 40.9% and 16.1% self-reported having any and ≥3 types of long COVID symptoms, respectively. After adjusting for significant variables related to sociodemographic characteristics, health conditions and lifestyles, and SARS-CoV-2 infection, receiving at least three doses of COVID-19 vaccines was associated with lower odds of reporting any long COVID symptoms comparing to receiving two doses (adjusted odds ratio [AOR]: 0.69, 95% CI: 0.54, 0.87,
P = .002). Three doses of inactivated and mRNA vaccines had similar protective effects against long COVID symptoms. It is important to strengthen the coverage of COVID-19 vaccination booster doses, even in the post-pandemic era.
KW - Long COVID
KW - booster
KW - inactivated vaccines
KW - mRNA vaccines
KW - post-COVID-19 condition
KW - post-acute sequelae of COVID- 19
KW - vaccination
UR - https://www.cambridge.org/core/journals/epidemiology-and-infection/article/receiving-three-doses-of-inactivated-or-mrna-covid19-vaccines-was-associated-with-lower-odds-of-long-covid-symptoms-among-people-with-a-history-of-sarscov2-infection-in-hong-kong-china-a-crosssectional-survey-study/28D381BBFD240D695A81901C0AF12D58
U2 - 10.1017/S0950268824001687
DO - 10.1017/S0950268824001687
M3 - Journal article
C2 - 39659228
SN - 0950-2688
VL - 152
SP - e166
JO - Epidemiology and Infection
JF - Epidemiology and Infection
M1 - e166
ER -
