Rebalancing metal dyshomeostasis for Alzheimer’s disease therapy

Guan Jun Yang, Hao Liu, Edmond Dik Lung MA, Chung Hang Leung*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Alzheimer’s disease (AD) is a type of neurodegenerative malady that is associated with the accumulation of amyloid plaques. Metal ions are critical for the development and upkeep of brain activity, but metal dyshomeostasis can contribute to the development of neurodegenerative diseases, including AD. This review highlights the association between metal dyshomeostasis and AD pathology, the feasibility of rebalancing metal homeostasis as a therapeutic strategy for AD, and a survey of current drugs that action via rebalancing metal homeostasis. Finally, we discuss the challenges that should be overcome by researchers in the future to enable the practical use of metal homeostasis rebalancing agents for clinical application.

Original languageEnglish
Pages (from-to)1159-1170
Number of pages12
JournalJournal of Biological Inorganic Chemistry
Volume24
Issue number8
DOIs
Publication statusPublished - 1 Dec 2019

Scopus Subject Areas

  • Biochemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Alzheimer’s disease
  • Aβ aggregation inhibitors
  • Metal chelators
  • Metal dyshomeostasis
  • Metal ions
  • Multifunctional agents

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