TY - JOUR
T1 - Reactive oxygen species-responsive nanotherapy for the prevention and treatment of cerebral ischemia–reperfusion injury
AU - Kong, Jianglong
AU - Chu, Runxuan
AU - Wen, Junjie
AU - Yu, Hongrui
AU - Liu, Jiawen
AU - Sun, Yuting
AU - Mao, Meiru
AU - Ge, Xiaohan
AU - Jin, Zixin
AU - Huang, Weimin
AU - Hu, Na
AU - Zhang, Yi
AU - Wang, David Y.
AU - Wang, Yi
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/8/15
Y1 - 2024/8/15
N2 - Vascular recanalization intervention is the primary recommended approach for the treatment of ischemic stroke. However, the damage caused by cerebral ischemia-reperfusion (I/R) poses a significant challenge for effective treatment. The aim of this study was to address this challenge by developing multifunctional nanoparticles (NPs). Cu4.6O NP was encapsulated by zein-Se-Se-DHA (Dz), the diselenide bond-conjugated zein and docosahexaenoic acid (DHA), and then coated by platelet membrane (PLTM) to form Cu4.6O@Dz@PLTM (MDzCu) NP. MDzCu with the PLTM coating showed strong targeting ability to the cerebral ischemic lesions in the rat model of cerebral I/R injury. Furthermore, in the reactive oxygen species (ROS)-rich brain microenvironment, both Cu4.6O and DHA are released from MDzCu, exerting ROS scavenging, promoting microglia polarization, and providing neuroprotective effects, ultimately alleviating cerebral I/R injury. This study presents several novel findings, such as the use of Cu0/Cu+ NPs for brain-related diseases, ROS scavenger-assisted DHA therapy for the central nervous system (CNS), and the application of stimuli-responsive NPs with diselenides to treat I/R injuries. This study provides insights into the development of stimuli-responsive nanomedicines with cell membrane coatings for the targeted treatment of brain diseases.
AB - Vascular recanalization intervention is the primary recommended approach for the treatment of ischemic stroke. However, the damage caused by cerebral ischemia-reperfusion (I/R) poses a significant challenge for effective treatment. The aim of this study was to address this challenge by developing multifunctional nanoparticles (NPs). Cu4.6O NP was encapsulated by zein-Se-Se-DHA (Dz), the diselenide bond-conjugated zein and docosahexaenoic acid (DHA), and then coated by platelet membrane (PLTM) to form Cu4.6O@Dz@PLTM (MDzCu) NP. MDzCu with the PLTM coating showed strong targeting ability to the cerebral ischemic lesions in the rat model of cerebral I/R injury. Furthermore, in the reactive oxygen species (ROS)-rich brain microenvironment, both Cu4.6O and DHA are released from MDzCu, exerting ROS scavenging, promoting microglia polarization, and providing neuroprotective effects, ultimately alleviating cerebral I/R injury. This study presents several novel findings, such as the use of Cu0/Cu+ NPs for brain-related diseases, ROS scavenger-assisted DHA therapy for the central nervous system (CNS), and the application of stimuli-responsive NPs with diselenides to treat I/R injuries. This study provides insights into the development of stimuli-responsive nanomedicines with cell membrane coatings for the targeted treatment of brain diseases.
KW - Ischemia-reperfusion
KW - Neuroprotection
KW - ROS scavenging
KW - Stimuli-responsive
KW - Targeted delivery
UR - http://www.scopus.com/inward/record.url?scp=85196417515&partnerID=8YFLogxK
U2 - 10.1016/j.cej.2024.153023
DO - 10.1016/j.cej.2024.153023
M3 - Journal article
AN - SCOPUS:85196417515
SN - 1385-8947
VL - 494
JO - Chemical Engineering Journal
JF - Chemical Engineering Journal
M1 - 153023
ER -
