Rational designing of oscillatory rhythmicity for memory rescue in plasticity-impaired learning networks

Kwan Tung Li, Xingzhi He, Guangjun Zhou, Jing Yang, Tao Li, Hailan Hu, Daoyun Ji, Changsong Zhou*, Huan Ma*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In the brain, oscillatory strength embedded in network rhythmicity is important for processing experiences, and this process is disrupted in certain psychiatric disorders. The use of rhythmic network stimuli can change these oscillations and has shown promise in terms of improving cognitive function, although the underlying mechanisms are poorly understood. Here, we combine a two-layer learning model, with experiments involving genetically modified mice, that provides precise control of experience-driven oscillations by manipulating long-term potentiation of excitatory synapses onto inhibitory interneurons (LTPEI). We find that, in the absence of LTPEI, impaired network dynamics and memory are rescued by activating inhibitory neurons to augment the power in theta and gamma frequencies, which prevents network overexcitation with less inhibitory rebound. In contrast, increasing either theta or gamma power alone was less effective. Thus, inducing network changes at dual frequencies is involved in memory encoding, indicating a potentially feasible strategy for optimizing network-stimulating therapies.

Original languageEnglish
Article number110678
Number of pages22
JournalCell Reports
Volume39
Issue number2
DOIs
Publication statusPublished - 12 Apr 2022

Scopus Subject Areas

  • Biochemistry, Genetics and Molecular Biology(all)

User-Defined Keywords

  • brain stimulation
  • CaMKII
  • CP: Neuroscience
  • inhibitory interneurons
  • learning and memory
  • long-term memory
  • LTP
  • network plasticity
  • network stimuli
  • oscillations
  • synaptic plasticity

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