Abstract
1. A liquid chromatography–mass spectrometry method was developed to detect and characterise aristocholic acid–DNA adducts in biological samples.
2. The detection of DNA adducts in plasma, urine or the cells found in urine may be useful to support the diagnosis and monitoring of aristocholic acid–associated poisoning and disease.
3. Efforts should be made to improve the sensitivity and specificity of this approach for the detection and characterisation of exposure to other mutagens/carcinogens.
2. The detection of DNA adducts in plasma, urine or the cells found in urine may be useful to support the diagnosis and monitoring of aristocholic acid–associated poisoning and disease.
3. Efforts should be made to improve the sensitivity and specificity of this approach for the detection and characterisation of exposure to other mutagens/carcinogens.
| Original language | English |
|---|---|
| Pages (from-to) | S40-S43 |
| Number of pages | 4 |
| Journal | Hong Kong Medical Journal |
| Volume | 19 |
| Issue number | 6, Suppl 9 |
| Publication status | Published - Dec 2013 |
Scopus Subject Areas
- General Medicine