Quercetin Mediated Reduction of Angiogenic Markers and Chaperones in DLA-Induced Solid Tumours

Kushi Anand, Pallavi Asthana, Anup Kumar, Rashmi K Ambasta, Pravir Kumar*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

17 Citations (Scopus)

Abstract

Diet-derived flavonoids, in particular quercetin, may play advantageous roles by preventing or/and inhibiting oncogenesis. Evidence suggests that quercetin can elicit various properties depending on the cell type. The aim of this study was to evaluate its effects on Dalton's lymphoma ascites (DLA) induced solid tumours and to identify the target(s) of action. We addressed this question by inducing subcutaneous solid tumours in Swiss albino mice and investigated whether the quercetin affects essential biological processes that are responsible for tumour growth, morphology, angiogenesis and apoptosis. We also studied influence on several heat shock proteins (HSPs). Our findings demonstrate that intra-tumour administration of quercetin results in decreased volume/weight. Furthermore, we demonstrate that quercetin promotes apoptosis of cancer cells by down-regulating the levels of Hsp90 and Hsp70. Depletion of these two chaperones by quercetin might result in triggering of caspase-3 in treated tumours. Moreover, it also down-regulated the expression of major key angiogenic or pro-angiogenic factors, like HIF-1α and VEGF In addition, H&E staining together with immunofluorescence of fixed tumour tissue provided evidence in support of increased cell death in quercetin -treated mice.

Original languageEnglish
Pages (from-to)2829-2835
Number of pages7
JournalAsian Pacific Journal of Cancer Prevention
Volume12
Issue number11
Publication statusPublished - Nov 2011

Scopus Subject Areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

User-Defined Keywords

  • Apoptosis
  • DLA
  • Heat shock proteins
  • HIF-1α
  • Quercetin
  • VEGF

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