Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng

Jing Rong Wang, Chiu Yin Leung, Hing Man Ho, Stella Chai, Lee Fong Yau, Zhongzhen ZHAO, Zhi Hong JIANG*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

27 Citations (Scopus)


Quantitative comparison of seven ginsenosides in wild and cultivated American ginseng revealed that the Rg1/Rd ratio presented a significantly large difference between cultivated and type-I (one of the defined chemotypes) wild American ginseng, facilitating this ratio as a characteristic marker for differentiating these two groups. Similarly, the ratio (Rg 1 + Re)/Rd, and the ratio of protopanaxatriol (PPT)-type ginsenosides to protopanaxadiol (PPD)-type ginsenosides showed a large difference between these two groups. On the other hand, type-II wild samples were found to have high Rg1/Rb1 and Rg1/Re ratios and low panaxydol/panaxynol ratio, which is entirely different from Type-I American ginseng, but is very similar to that of Asian ginseng. This not only suggests that the chemotype should be taken into consideration properly when using these parameters for differentiating American and Asian ginseng, but also indicates that type-II wild American ginseng may have distinct pharmacological activities and therapeutic effects.

Original languageEnglish
Pages (from-to)975-983
Number of pages9
JournalChemistry and Biodiversity
Issue number4
Publication statusPublished - Apr 2010

Scopus Subject Areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology


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