Quantifying predictive capability of electronic health records for the most harmful breast cancer

Yirong Wu, Jun FAN, Peggy Peissig, Richard Berg, Ahmad Pahlavan Tafti, Jie Yin, Ming Yuan, David Page, Jennifer Cox, Elizabeth S. Burnside

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Improved prediction of the "most harmful" breast cancers that cause the most substantive morbidity and mortality would enable physicians to target more intense screening and preventive measures at those women who have the highest risk; however, such prediction models for the "most harmful" breast cancers have rarely been developed. Electronic health records (EHRs) represent an underused data source that has great research and clinical potential. Our goal was to quantify the value of EHR variables in the "most harmful" breast cancer risk prediction. We identified 794 subjects who had breast cancer with primary non-benign tumors with their earliest diagnosis on or after 1/1/2004 from an existing personalized medicine data repository, including 395 "most harmful" breast cancer cases and 399 "least harmful" breast cancer cases. For these subjects, we collected EHR data comprised of 6 components: demographics, diagnoses, symptoms, procedures, medications, and laboratory results. We developed two regularized prediction models, Ridge Logistic Regression (Ridge-LR) and Lasso Logistic Regression (Lasso-LR), to predict the "most harmful" breast cancer one year in advance. The area under the ROC curve (AUC) was used to assess model performance. We observed that the AUCs of Ridge-LR and Lasso-LR models were 0.818 and 0.839 respectively. For both the Ridge-LR and LassoLR models, the predictive performance of the whole EHR variables was significantly higher than that of each individual component (p<0.001). In conclusion, EHR variables can be used to predict the "most harmful" breast cancer, providing the possibility to personalize care for those women at the highest risk in clinical practice.

Original languageEnglish
Title of host publicationMedical Imaging 2018
Subtitle of host publicationImage Perception, Observer Performance, and Technology Assessment
EditorsFrank W. Samuelson, Robert M. Nishikawa
PublisherSPIE
ISBN (Electronic)9781510616431
DOIs
Publication statusPublished - 2018
EventMedical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment - Houston, United States
Duration: 11 Feb 201812 Feb 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10577
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment
Country/TerritoryUnited States
CityHouston
Period11/02/1812/02/18

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

User-Defined Keywords

  • breast cancer
  • electronic health records (EHRs)
  • least absolute shrinkage and selection operator (Lasso)
  • regularized prediction model

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