Putrescine biosynthesis in Tetrahymena thermophila.

K. M. Yao*, David W F FONG, S. F. Ng

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

8 Citations (Scopus)


The putrescine-biosynthesis pathway in Tetrahymena thermophila was delineated by studying crude extracts prepared from exponentially growing cultures. A pyridoxal phosphate-stimulated ornithine decarboxylase activity competitively inhibited by putrescine was detected. CO2 was also liberated from L-arginine, but analyses by t.l.c. and enzyme studies suggested that the activity was not due to arginine decarboxylase, nor could enzyme activities converting agmatine into putrescine be detected. We conclude that the decarboxylation of L-ornithine is probably the only major route for putrescine biosynthesis in this organism during exponential growth.

Original languageEnglish
Pages (from-to)679-684
Number of pages6
JournalBiochemical Journal
Issue number3
Publication statusPublished - 15 Sept 1984

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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