TY - JOUR
T1 - Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI
AU - Wang, Yuxin
AU - Jiang, Zhiqi
AU - Chu, Chunguang
AU - Zhang, Zhen
AU - Wang, Jiang
AU - Li, Dianyou
AU - He, Naying
AU - Fietkiewicz, Chris
AU - Zhou, Changsong
AU - Kaiser, Marcus
AU - Bai, Xuze
AU - Zhang, Chencheng
AU - Liu, Chen
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China under Grant 62173241, the STI2030-Major Projects under Grant 2022ZD0205300, the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation under Grant Number GZC20230529, the National Natural Science Foundation of China under grant 82401483, and the China Postdoctoral Science Foundation under Grant Number 2023M740711.
Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson’s disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 healthy controls. The model fits microscopic coupling parameters in the cortico-basal ganglia-thalamic neural loop to match individual connectivity, finding the “push-pull” effect of basal ganglia network. Specifically, increased GABAergic projection into the thalamus from basal ganglia worsens rigidity, while reduced GABAergic projection within the cortex exacerbates bradykinesia, suggesting that the dopamine deficiency induces the chain coupling variations to “push” the network to an abnormal state. Conversely, DBS can alleviate rigidity by enhancing GABAergic projections within the basal ganglia, and improve bradykinesia by reducing cortical projections to basal ganglia, exhibiting that DBS “pulls” the network to a healthy state. This work combines the microscopic and macroscopic neural information for understanding PD and its treatment.
AB - Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson’s disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 healthy controls. The model fits microscopic coupling parameters in the cortico-basal ganglia-thalamic neural loop to match individual connectivity, finding the “push-pull” effect of basal ganglia network. Specifically, increased GABAergic projection into the thalamus from basal ganglia worsens rigidity, while reduced GABAergic projection within the cortex exacerbates bradykinesia, suggesting that the dopamine deficiency induces the chain coupling variations to “push” the network to an abnormal state. Conversely, DBS can alleviate rigidity by enhancing GABAergic projections within the basal ganglia, and improve bradykinesia by reducing cortical projections to basal ganglia, exhibiting that DBS “pulls” the network to a healthy state. This work combines the microscopic and macroscopic neural information for understanding PD and its treatment.
UR - http://www.scopus.com/inward/record.url?scp=85209732004&partnerID=8YFLogxK
U2 - 10.1038/s41531-024-00835-7
DO - 10.1038/s41531-024-00835-7
M3 - Journal article
AN - SCOPUS:85209732004
SN - 2373-8057
VL - 10
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
IS - 1
M1 - 224
ER -