@techreport{f4fbe36e745e4c48873e81bd564f5e7d,
title = "Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex",
abstract = "Visual perception appears largely stable in time. However, psychophysical studies have revealed that theta waves (4-8 Hz) can modulate perception and have been linked to various cognitive states and functions. Neither the contribution of theta waves to cortical activity nor their impact during aberrant brain states have been resolved at high spatiotemporal scales. Here, using cortex-wide population voltage imaging in awake mice, we found that bouts of 5-Hz oscillations in the visual cortex are accompanied by similar oscillations in the retrosplenial cortex, occurring both spontaneously and evoked by visual stimulation. Injection of psychotropic 5-HT2AR agonist induced a significant increase in spontaneous 5-Hz oscillations, and also increased the power, occurrence probability and temporal persistence of visually evoked 5-Hz oscillations. This modulation of 5-Hz oscillations in both cortical areas indicates a strengthening of top-down control of perception, supporting an underlying mechanism of perceptual filling and visual hallucinations.",
author = "White, {Callum M} and Zohre Azimi and Robert Staadt and Chenchen Song and Thomas Kn{\"o}pfel and Dirk Jancke",
note = "Funder Information Declared Deutsche Forschungsgemeinschaft, Project ID 122679504 - SFB 874, JA 945/5-1, Project number 492434978 - GRK 2862/1, Subproject 10, BMBF, ERA-Net Neuron “Horizon 2020”, 01EW2104B National Institutes of Health, 5U01NS099573 Lee Kuan Yew Postdoctoral Fellowship, 022506-00001 National Medical Research Council, https://ror.org/04x3cxs03, MOH-001720",
year = "2025",
month = jul,
day = "6",
doi = "10.1101/2025.07.05.663288",
language = "English",
series = "bioRxiv",
publisher = "Cold Spring Harbor Laboratory Press",
address = "United States",
type = "WorkingPaper",
institution = "Cold Spring Harbor Laboratory Press",
}