Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

Hongjie ZHANG; Zhuting Fan; Ghee T. Tan; Hee Byung Chai; John M. Pezzuto; Handong Sun; Harry H.S. Fong

doi:10.1021/np010420h

Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

Hongjie ZHANG
, Zhuting Fan
, Ghee T. Tan
, Hee Byung Chai
, John M. Pezzuto
, Handong Sun^*
, Harry H.S. Fong

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC₅₀ values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

Original language	English
Pages (from-to)	215-217
Number of pages	3
Journal	Journal of Natural Products
Volume	65
Issue number	2
DOIs	https://doi.org/10.1021/np010420h
Publication status	Published - 1 Feb 2002

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title = "Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata",

abstract = "A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.",

author = "Hongjie ZHANG and Zhuting Fan and Tan, \{Ghee T.\} and Chai, \{Hee Byung\} and Pezzuto, \{John M.\} and Handong Sun and Fong, \{Harry H.S.\}",

year = "2002",

month = feb,

day = "1",

doi = "10.1021/np010420h",

language = "English",

volume = "65",

pages = "215--217",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

AU - ZHANG, Hongjie

AU - Fan, Zhuting

AU - Tan, Ghee T.

AU - Chai, Hee Byung

AU - Pezzuto, John M.

AU - Sun, Handong

AU - Fong, Harry H.S.

PY - 2002/2/1

Y1 - 2002/2/1

N2 - A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

AB - A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

UR - https://www.scopus.com/pages/publications/0036176893

U2 - 10.1021/np010420h

DO - 10.1021/np010420h

M3 - Journal article

C2 - 11858760

AN - SCOPUS:0036176893

SN - 0163-3864

VL - 65

SP - 215

EP - 217

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

Abstract

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