TY - JOUR
T1 - Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata
AU - ZHANG, Hongjie
AU - Fan, Zhuting
AU - Tan, Ghee T.
AU - Chai, Hee Byung
AU - Pezzuto, John M.
AU - Sun, Handong
AU - Fong, Harry H.S.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.
AB - A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.
UR - http://www.scopus.com/inward/record.url?scp=0036176893&partnerID=8YFLogxK
U2 - 10.1021/np010420h
DO - 10.1021/np010420h
M3 - Journal article
C2 - 11858760
AN - SCOPUS:0036176893
SN - 0163-3864
VL - 65
SP - 215
EP - 217
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -
