Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

Hongjie ZHANG; Zhuting Fan; Ghee T. Tan; Hee Byung Chai; John M. Pezzuto; Handong Sun; Harry H.S. Fong

doi:10.1021/np010420h

Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

Hongjie ZHANG, Zhuting Fan, Ghee T. Tan, Hee Byung Chai, John M. Pezzuto, Handong Sun^*, Harry H.S. Fong

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC₅₀ values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

Original language	English
Pages (from-to)	215-217
Number of pages	3
Journal	Journal of Natural Products
Volume	65
Issue number	2
DOIs	https://doi.org/10.1021/np010420h
Publication status	Published - 2002

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata",

abstract = "A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.",

author = "Hongjie ZHANG and Zhuting Fan and Tan, {Ghee T.} and Chai, {Hee Byung} and Pezzuto, {John M.} and Handong Sun and Fong, {Harry H.S.}",

year = "2002",

doi = "10.1021/np010420h",

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volume = "65",

pages = "215--217",

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T1 - Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

AU - ZHANG, Hongjie

AU - Fan, Zhuting

AU - Tan, Ghee T.

AU - Chai, Hee Byung

AU - Pezzuto, John M.

AU - Sun, Handong

AU - Fong, Harry H.S.

PY - 2002

Y1 - 2002

N2 - A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

AB - A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

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DO - 10.1021/np010420h

M3 - Journal article

C2 - 11858760

AN - SCOPUS:0036176893

SN - 0163-3864

VL - 65

SP - 215

EP - 217

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

Abstract

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