Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

Hongjie ZHANG, Zhuting Fan, Ghee T. Tan, Hee Byung Chai, John M. Pezzuto, Handong Sun*, Harry H.S. Fong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS cancer cell lines with IC50 values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) μg/mL (μM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

Original languageEnglish
Pages (from-to)215-217
Number of pages3
JournalJournal of Natural Products
Volume65
Issue number2
DOIs
Publication statusPublished - 2002

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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