Protopanaxatriol-type ginsenosides from the root of Panax ginseng

Guo Yuan Zhu; Ying Wei Li; Desmond Kwok Po Hau; Zhi Hong JIANG; Zhiling YU; David W F FONG

doi:10.1021/jf1037932

Protopanaxatriol-type ginsenosides from the root of Panax ginseng

Guo Yuan Zhu, Ying Wei Li, Desmond Kwok Po Hau, Zhi Hong JIANG, Zhiling YU, David W F FONG^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

63 Citations (Scopus)

Abstract

Ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae), is one of the most important traditional medicines and functional foods. A detailed phytochemical investigation on the roots of P. ginseng led to the isolation of 6 new natural protopanaxatriol (PPT)-type ginsenosides, ginsenosides Re ₁-Re₆ (compounds 1-6), along with 10 known PPT-type ginsenosides. Their structures were elucidated on the basis of chemical and spectroscopic analyses, including high-resolution mass spectrometry (HRMS) and 1D and 2D nuclear magnetic resonance (NMR). The unusual α-d- glucopyranosyl-(1→3)-β-d-glucopyranosyl sugar chain, as found in compounds 1 and 2, is reported in the genus Panax for the first time.

Original language	English
Pages (from-to)	200-205
Number of pages	6
Journal	Journal of Agricultural and Food Chemistry
Volume	59
Issue number	1
DOIs	https://doi.org/10.1021/jf1037932
Publication status	Published - 12 Jan 2011

Scopus Subject Areas

Chemistry(all)
Agricultural and Biological Sciences(all)

User-Defined Keywords

Araliaceae
ginsenoside
ginsenosides Re-Re
Panax ginseng
protopanaxatriol

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10.1021/jf1037932

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title = "Protopanaxatriol-type ginsenosides from the root of Panax ginseng",

abstract = "Ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae), is one of the most important traditional medicines and functional foods. A detailed phytochemical investigation on the roots of P. ginseng led to the isolation of 6 new natural protopanaxatriol (PPT)-type ginsenosides, ginsenosides Re 1-Re6 (compounds 1-6), along with 10 known PPT-type ginsenosides. Their structures were elucidated on the basis of chemical and spectroscopic analyses, including high-resolution mass spectrometry (HRMS) and 1D and 2D nuclear magnetic resonance (NMR). The unusual α-d- glucopyranosyl-(1→3)-β-d-glucopyranosyl sugar chain, as found in compounds 1 and 2, is reported in the genus Panax for the first time.",

keywords = "Araliaceae, ginsenoside, ginsenosides Re-Re, Panax ginseng, protopanaxatriol",

author = "Zhu, {Guo Yuan} and Li, {Ying Wei} and Hau, {Desmond Kwok Po} and JIANG, {Zhi Hong} and Zhiling YU and FONG, {David W F}",

note = "The project was supported by a Faculty Research Grant of the Hong Kong Baptist University. ",

year = "2011",

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doi = "10.1021/jf1037932",

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journal = "Journal of Agricultural and Food Chemistry",

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T1 - Protopanaxatriol-type ginsenosides from the root of Panax ginseng

AU - Zhu, Guo Yuan

AU - Li, Ying Wei

AU - Hau, Desmond Kwok Po

AU - JIANG, Zhi Hong

AU - YU, Zhiling

AU - FONG, David W F

N1 - The project was supported by a Faculty Research Grant of the Hong Kong Baptist University.

PY - 2011/1/12

Y1 - 2011/1/12

N2 - Ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae), is one of the most important traditional medicines and functional foods. A detailed phytochemical investigation on the roots of P. ginseng led to the isolation of 6 new natural protopanaxatriol (PPT)-type ginsenosides, ginsenosides Re 1-Re6 (compounds 1-6), along with 10 known PPT-type ginsenosides. Their structures were elucidated on the basis of chemical and spectroscopic analyses, including high-resolution mass spectrometry (HRMS) and 1D and 2D nuclear magnetic resonance (NMR). The unusual α-d- glucopyranosyl-(1→3)-β-d-glucopyranosyl sugar chain, as found in compounds 1 and 2, is reported in the genus Panax for the first time.

AB - Ginseng, the root of Panax ginseng C. A. Meyer (Araliaceae), is one of the most important traditional medicines and functional foods. A detailed phytochemical investigation on the roots of P. ginseng led to the isolation of 6 new natural protopanaxatriol (PPT)-type ginsenosides, ginsenosides Re 1-Re6 (compounds 1-6), along with 10 known PPT-type ginsenosides. Their structures were elucidated on the basis of chemical and spectroscopic analyses, including high-resolution mass spectrometry (HRMS) and 1D and 2D nuclear magnetic resonance (NMR). The unusual α-d- glucopyranosyl-(1→3)-β-d-glucopyranosyl sugar chain, as found in compounds 1 and 2, is reported in the genus Panax for the first time.

KW - Araliaceae

KW - ginsenoside

KW - ginsenosides Re-Re

KW - Panax ginseng

KW - protopanaxatriol

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DO - 10.1021/jf1037932

M3 - Journal article

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AN - SCOPUS:78651107135

SN - 0021-8561

VL - 59

SP - 200

EP - 205

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

IS - 1

ER -

Protopanaxatriol-type ginsenosides from the root of Panax ginseng

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