TY - JOUR
T1 - Protocol for Brain Magnetic Resonance Imaging and Extraction of Imaging-Derived Phenotypes from the China Phenobank Project
AU - Wang, Chengyan
AU - Shi, Zhang
AU - Li, Yan
AU - Xia, Xueqin
AU - Kuang, Xutong
AU - Qian, Shufang
AU - Xue, Le
AU - Lan, Lizhen
AU - Wu, Yudan
AU - Zhang, Na
AU - Tao, Ji
AU - Hu, Xumei
AU - Cao, Wenzhao
AU - He, Naying
AU - Guo, Yike
AU - Chen, Weibo
AU - Zhang, Jun
AU - Luo, Jingchun
AU - Wang, He
AU - Tian, Mei
N1 - Funding Information:
This study was funded by the Shanghai Municipal Science and Technology Major Project (No. 2017SHZDZX01).
Publisher Copyright:
© International Human Phenome Institutes (Shanghai) 2023
PY - 2023/12
Y1 - 2023/12
N2 - Imaging-derived phenotypes (IDPs) have been increasingly used in population-based cohort studies in recent years. As widely reported, magnetic resonance imaging (MRI) is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast. The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project (CHPP). Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP. The brain imaging sequences included T1-magnetization that prepared rapid gradient echo, T2 fluid-attenuated inversion-recovery, magnetic resonance angiography, diffusion MRI, and resting-state functional MRI. The detailed descriptions of image acquisition, interpretation, and post-processing were provided in this article. The measured IDPs included volumes of brain subregions, cerebral vessel geometrical parameters, microstructural tracts, and function connectivity metrics.
AB - Imaging-derived phenotypes (IDPs) have been increasingly used in population-based cohort studies in recent years. As widely reported, magnetic resonance imaging (MRI) is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast. The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project (CHPP). Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP. The brain imaging sequences included T1-magnetization that prepared rapid gradient echo, T2 fluid-attenuated inversion-recovery, magnetic resonance angiography, diffusion MRI, and resting-state functional MRI. The detailed descriptions of image acquisition, interpretation, and post-processing were provided in this article. The measured IDPs included volumes of brain subregions, cerebral vessel geometrical parameters, microstructural tracts, and function connectivity metrics.
KW - Brain magnetic resonance imaging
KW - Human phenome project
KW - Imaging derived phenotypes
KW - Phenobank
KW - Standard protocol
UR - http://www.scopus.com/inward/record.url?scp=85173231809&partnerID=8YFLogxK
U2 - 10.1007/s43657-022-00083-w
DO - 10.1007/s43657-022-00083-w
M3 - Journal article
AN - SCOPUS:85173231809
SN - 2730-583X
VL - 3
SP - 642
EP - 656
JO - Phenomics
JF - Phenomics
IS - 6
ER -
