Protein surface recognition of the novel tetra-carboxylphenyl calix[4]arene to cytochrome c

Wen Ting An; Yong Jiao; Xiao Hua Sun; Chuan Dong; Shao Min Shuang; Ping Fang Xia; Man Shing Wong

doi:10.1016/j.cclet.2008.09.004

Protein surface recognition of the novel tetra-carboxylphenyl calix[4]arene to cytochrome c

Wen Ting An, Yong Jiao, Xiao Hua Sun, Chuan Dong, Shao Min Shuang, Ping Fang Xia, Man Shing Wong

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

Abstract

The interaction of the novel tetra-carboxylphenyl calix[4]arene (TCPC) with the bovine heart cytochrome c (Cc) was first investigated by fluorescence spectroscopy and molecular modeling methods. The formation of a stable 1:1 complex was monitored by fluorescence titration, and its binding constant is 1.916 × 10⁷ L mol⁻¹. Molecular modeling reveals the recognition mechanism of TCPC to the Cc surface, that is, the electrostatic interaction drives TCPC to the Cc surface, and the van der Waals interaction orientates TCPC parallel to the cleft of Cc.

Original language	English
Pages (from-to)	1341-1344
Number of pages	4
Journal	Chinese Chemical Letters
Volume	19
Issue number	11
Early online date	23 Oct 2008
DOIs	https://doi.org/10.1016/j.cclet.2008.09.004
Publication status	Published - Nov 2008

User-Defined Keywords

Tetra-carboxylphenyl calix[4]arene
Cytochrome c
Protein surface recognition
Fluorescence spectroscopy
Molecular modeling

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10.1016/j.cclet.2008.09.004

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title = "Protein surface recognition of the novel tetra-carboxylphenyl calix[4]arene to cytochrome c",

abstract = "The interaction of the novel tetra-carboxylphenyl calix[4]arene (TCPC) with the bovine heart cytochrome c (Cc) was first investigated by fluorescence spectroscopy and molecular modeling methods. The formation of a stable 1:1 complex was monitored by fluorescence titration, and its binding constant is 1.916 × 107 L mol−1. Molecular modeling reveals the recognition mechanism of TCPC to the Cc surface, that is, the electrostatic interaction drives TCPC to the Cc surface, and the van der Waals interaction orientates TCPC parallel to the cleft of Cc.",

keywords = "Tetra-carboxylphenyl calix[4]arene, Cytochrome c, Protein surface recognition, Fluorescence spectroscopy, Molecular modeling",

author = "An, {Wen Ting} and Yong Jiao and Sun, {Xiao Hua} and Chuan Dong and Shuang, {Shao Min} and Xia, {Ping Fang} and Wong, {Man Shing}",

year = "2008",

month = nov,

doi = "10.1016/j.cclet.2008.09.004",

language = "English",

volume = "19",

pages = "1341--1344",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

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TY - JOUR

T1 - Protein surface recognition of the novel tetra-carboxylphenyl calix[4]arene to cytochrome c

AU - An, Wen Ting

AU - Jiao, Yong

AU - Sun, Xiao Hua

AU - Dong, Chuan

AU - Shuang, Shao Min

AU - Xia, Ping Fang

AU - Wong, Man Shing

PY - 2008/11

Y1 - 2008/11

N2 - The interaction of the novel tetra-carboxylphenyl calix[4]arene (TCPC) with the bovine heart cytochrome c (Cc) was first investigated by fluorescence spectroscopy and molecular modeling methods. The formation of a stable 1:1 complex was monitored by fluorescence titration, and its binding constant is 1.916 × 107 L mol−1. Molecular modeling reveals the recognition mechanism of TCPC to the Cc surface, that is, the electrostatic interaction drives TCPC to the Cc surface, and the van der Waals interaction orientates TCPC parallel to the cleft of Cc.

AB - The interaction of the novel tetra-carboxylphenyl calix[4]arene (TCPC) with the bovine heart cytochrome c (Cc) was first investigated by fluorescence spectroscopy and molecular modeling methods. The formation of a stable 1:1 complex was monitored by fluorescence titration, and its binding constant is 1.916 × 107 L mol−1. Molecular modeling reveals the recognition mechanism of TCPC to the Cc surface, that is, the electrostatic interaction drives TCPC to the Cc surface, and the van der Waals interaction orientates TCPC parallel to the cleft of Cc.

KW - Tetra-carboxylphenyl calix[4]arene

KW - Cytochrome c

KW - Protein surface recognition

KW - Fluorescence spectroscopy

KW - Molecular modeling

U2 - 10.1016/j.cclet.2008.09.004

DO - 10.1016/j.cclet.2008.09.004

M3 - Journal article

SN - 1001-8417

VL - 19

SP - 1341

EP - 1344

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 11

ER -

Protein surface recognition of the novel tetra-carboxylphenyl calix[4]arene to cytochrome c

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