Protein surface recognition of the novel tetra-carboxylphenyl calix[4]arene to cytochrome c

Wen Ting An, Yong Jiao, Xiao Hua Sun, Chuan Dong, Shao Min Shuang, Ping Fang Xia, Man Shing Wong

Research output: Contribution to journalArticlepeer-review

Abstract

The interaction of the novel tetra-carboxylphenyl calix[4]arene (TCPC) with the bovine heart cytochrome c (Cc) was first investigated by fluorescence spectroscopy and molecular modeling methods. The formation of a stable 1:1 complex was monitored by fluorescence titration, and its binding constant is 1.916 × 107 L mol−1. Molecular modeling reveals the recognition mechanism of TCPC to the Cc surface, that is, the electrostatic interaction drives TCPC to the Cc surface, and the van der Waals interaction orientates TCPC parallel to the cleft of Cc.
Original languageEnglish
Pages (from-to)1341-1344
Number of pages4
JournalChinese Chemical Letters
Volume19
Issue number11
Early online date23 Oct 2008
DOIs
Publication statusPublished - Nov 2008

User-Defined Keywords

  • Tetra-carboxylphenyl calix[4]arene
  • Cytochrome c
  • Protein surface recognition
  • Fluorescence spectroscopy
  • Molecular modeling

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