Protein degrons and degradation: Exploring substrate recognition and pathway selection in plants

Erika Isono, Jianming Li, Pablo Pulido, Wei Siao, Steven H. Spoel, Zhishuo Wang, Xiaohong Zhuang, Marco Trujillo*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

Proteome composition is dynamic and influenced by many internal and external cues, including developmental signals, light availability, or environmental stresses. Protein degradation, in synergy with protein biosynthesis, allows cells to respond to various stimuli and adapt by reshaping the proteome. Protein degradation mediates the final and irreversible disassembly of proteins, which is important for protein quality control and to eliminate misfolded or damaged proteins, as well as entire organelles. Consequently, it contributes to cell resilience by buffering against protein or organellar damage caused by stresses. Moreover, protein degradation plays important roles in cell signaling, as well as transcriptional and translational events. The intricate task of recognizing specific proteins for degradation is achieved by specialized systems that are tailored to the substrate's physicochemical properties and subcellular localization. These systems recognize diverse substrate cues collectively referred to as “degrons,” which can assume a range of configurations. They are molecular surfaces recognized by E3 ligases of the ubiquitin-proteasome system but can also be considered as general features recognized by other degradation systems, including autophagy or even organellar proteases. Here we provide an overview of the newest developments in the field, delving into the intricate processes of protein recognition and elucidating the pathways through which they are recruited for degradation.
Original languageEnglish
Pages (from-to)1-25
Number of pages25
JournalPlant Cell
DOIs
Publication statusE-pub ahead of print - 3 May 2024

Fingerprint

Dive into the research topics of 'Protein degrons and degradation: Exploring substrate recognition and pathway selection in plants'. Together they form a unique fingerprint.

Cite this