Protective effect of Dendrobium officinale polysaccharides on experimental Sjogren's syndrome

Xiang Lin, Stephen Cho Wing Sze, Yao Tong, Zhangjin Zhang, Yibin Feng, Jian ping Chen, Tzi Bun Ng, Xiao Lin, P. C. Shaw, Kalin Yanbo Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Sjogren's syndrome (SS), usually described as a chronic inflammation which results in xerostomia (dry mouth) and xerophthalmia (dry eyes). According to the theory of traditional Chinese medicine, body fluid impairment causes the dryness, inducing water secretion deficiency. Discovery of a family of water-specific membrane channel proteins, the aquaporins, provides an interesting molecular mechanism of water permeability and transportation which were found abnormal in tissues of SS patients. Thus, this dryness may lead to the dysfunction in organs as various systematic manifestations. We established an autoallergic mouse model in vivo, and human salivary gland cell line A-253 in vitro. Polysaccharides of Dendrobium officinale (DP) were administrated as treatment, which was described to nourish yin and promote the body fluid. Results showed that immunization with SG autoantigen induced decrease of body weight and increased water intake, decreased AQP5 expression in a series of organs related to body fluid. Sera from model mice induced apoptosis of A-253 cells with activation of caspase-3. Administration of DP could reverse these pathological changes in both the animal and cell model. Thus, DP may be a promising candidate for the treatment of SS by up-regulating the expression of AQP-5 and protecting cells from apoptosis.
Original languageEnglish
Article number14
JournalJournal of Complementary and Integrative Medicine
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

User-Defined Keywords

  • Dendrobium officinale
  • polysaccharides
  • AQP5
  • Sjogren's syndrome
  • apoptosis

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