Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis

Jie Huang, Xuekun Fu, Xinxin Chen, Zheng Li, Yuhong Huang, Chao Liang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

107 Citations (Scopus)


Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that mainly damages the hands and feet, which affects 0.5% to 1.0% of the population worldwide. With the sustained development of disease-modifying antirheumatic drugs (DMARDs), significant success has been achieved for preventing and relieving disease activity in RA patients. Unfortunately, some patients still show limited response to DMARDs, which puts forward new requirements for special targets and novel therapies. Understanding the pathogenetic roles of the various molecules in RA could facilitate discovery of potential therapeutic targets and approaches. In this review, both existing and emerging targets, including the proteins, small molecular metabolites, and epigenetic regulators related to RA, are discussed, with a focus on the mechanisms that result in inflammation and the development of new drugs for blocking the various modulators in RA.
Original languageEnglish
Article number686155
Number of pages23
JournalFrontiers in Immunology
Publication statusPublished - 9 Jul 2021

Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

User-Defined Keywords

  • epigenetic regulators
  • proteins
  • rheumatoid arthritis
  • small molecular metabolites
  • targets


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