Progress and challenges in developing aptamer-functionalized targeted drug delivery systems

Feng Jiang; Biao Liu; Jun Lu; Fangfei Li; Defang Li; Chao Liang; Lei Dang; Jin Liu; Bing He; Shaikh Atik Badshah; Cheng Lu; Xiaojuan He; Baosheng Guo; Xiao Bing Zhang; Weihong Tan; Aiping Lyu; Ge Zhang

doi:10.3390/ijms161023784

Progress and challenges in developing aptamer-functionalized targeted drug delivery systems

Feng Jiang, Biao Liu, Jun Lu, Fangfei Li, Defang Li, Chao Liang, Lei Dang, Jin Liu, Bing He, Shaikh Atik Badshah, Cheng Lu, Xiaojuan He, Baosheng Guo, Xiao Bing Zhang^*, Weihong Tan^*, Aiping Lyu^*, Ge Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

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Abstract

Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

Original language	English
Pages (from-to)	23784-23822
Number of pages	39
Journal	International Journal of Molecular Sciences
Volume	16
Issue number	10
DOIs	https://doi.org/10.3390/ijms161023784
Publication status	Published - 9 Oct 2015

User-Defined Keywords

Aptamer
Aptamer-functionalized targeted drug delivery systems
Aptamer-nanomaterial conjugated systems
Aptamer-small molecule conjugated systems
SELEX

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Jiang, F., Liu, B., Lu, J., Li, F., Li, D., Liang, C., Dang, L., Liu, J., He, B., Badshah, S. A., Lu, C., He, X., Guo, B., Zhang, X. B., Tan, W., Lyu, A., & Zhang, G. (2015). Progress and challenges in developing aptamer-functionalized targeted drug delivery systems. International Journal of Molecular Sciences, 16(10), 23784-23822. https://doi.org/10.3390/ijms161023784

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abstract = "Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.",

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AU - Jiang, Feng

AU - Liu, Biao

AU - Lu, Jun

AU - Li, Fangfei

AU - Li, Defang

AU - Liang, Chao

AU - Dang, Lei

AU - Liu, Jin

AU - He, Bing

AU - Badshah, Shaikh Atik

AU - Lu, Cheng

AU - He, Xiaojuan

AU - Guo, Baosheng

AU - Zhang, Xiao Bing

AU - Tan, Weihong

AU - Lyu, Aiping

AU - Zhang, Ge

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AB - Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

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KW - Aptamer-functionalized targeted drug delivery systems

KW - Aptamer-nanomaterial conjugated systems

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SN - 1661-6596

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

Progress and challenges in developing aptamer-functionalized targeted drug delivery systems

Abstract

User-Defined Keywords

UN SDGs

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