Progress and challenges in developing aptamer-functionalized targeted drug delivery systems

Feng Jiang, Biao Liu, Jun Lu, Fangfei LI, Defang LI, Chao LIANG, Lei Dang, Jin LIU, Bing He, Shaikh Atik Badshah, Cheng Lu, Xiaojuan He, Baosheng GUO, Xiao Bing Zhang*, Weihong Tan, Aiping LYU, Ge ZHANG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)

Abstract

Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

Original languageEnglish
Pages (from-to)23784-23822
Number of pages39
JournalInternational Journal of Molecular Sciences
Volume16
Issue number10
DOIs
Publication statusPublished - 9 Oct 2015

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Aptamer
  • Aptamer-functionalized targeted drug delivery systems
  • Aptamer-nanomaterial conjugated systems
  • Aptamer-small molecule conjugated systems
  • SELEX

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