Progress and challenges in developing aptamer-functionalized targeted drug delivery systems

Feng Jiang; Biao Liu; Jun Lu; Fangfei LI; Defang LI; Chao LIANG; Lei Dang; Jin LIU; Bing He; Shaikh Atik Badshah; Cheng Lu; Xiaojuan He; Baosheng GUO; Xiao Bing Zhang; Weihong Tan; Aiping LYU; Ge ZHANG

doi:10.3390/ijms161023784

Progress and challenges in developing aptamer-functionalized targeted drug delivery systems

Feng Jiang, Biao Liu, Jun Lu, Fangfei LI, Defang LI, Chao LIANG, Lei Dang, Jin LIU, Bing He, Shaikh Atik Badshah, Cheng Lu, Xiaojuan He, Baosheng GUO, Xiao Bing Zhang^*, Weihong Tan, Aiping LYU, Ge ZHANG

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.

Original language	English
Pages (from-to)	23784-23822
Number of pages	39
Journal	International Journal of Molecular Sciences
Volume	16
Issue number	10
DOIs	https://doi.org/10.3390/ijms161023784
Publication status	Published - 9 Oct 2015

Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

User-Defined Keywords

Aptamer
Aptamer-functionalized targeted drug delivery systems
Aptamer-nanomaterial conjugated systems
Aptamer-small molecule conjugated systems
SELEX

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10.3390/ijms161023784

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Jiang, F., Liu, B., Lu, J., LI, F., LI, D., LIANG, C., Dang, L., LIU, J., He, B., Badshah, S. A., Lu, C., He, X., GUO, B., Zhang, X. B., Tan, W., LYU, A., & ZHANG, G. (2015). Progress and challenges in developing aptamer-functionalized targeted drug delivery systems. International Journal of Molecular Sciences, 16(10), 23784-23822. https://doi.org/10.3390/ijms161023784

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AU - Dang, Lei

AU - LIU, Jin

AU - He, Bing

AU - Badshah, Shaikh Atik

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Progress and challenges in developing aptamer-functionalized targeted drug delivery systems

Abstract

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