TY - JOUR
T1 - Progress and challenges in developing aptamer-functionalized targeted drug delivery systems
AU - Jiang, Feng
AU - Liu, Biao
AU - Lu, Jun
AU - Li, Fangfei
AU - Li, Defang
AU - Liang, Chao
AU - Dang, Lei
AU - Liu, Jin
AU - He, Bing
AU - Badshah, Shaikh Atik
AU - Lu, Cheng
AU - He, Xiaojuan
AU - Guo, Baosheng
AU - Zhang, Xiao Bing
AU - Tan, Weihong
AU - Lyu, Aiping
AU - Zhang, Ge
PY - 2015/10/9
Y1 - 2015/10/9
N2 - Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.
AB - Aptamers, which can be screened via systematic evolution of ligands by exponential enrichment (SELEX), are superior ligands for molecular recognition due to their high selectivity and affinity. The interest in the use of aptamers as ligands for targeted drug delivery has been increasing due to their unique advantages. Based on their different OPEN ACCESS compositions and preparation methods, aptamer-functionalized targeted drug delivery systems can be divided into two main categories: aptamer-small molecule conjugated systems and aptamer-nanomaterial conjugated systems. In this review, we not only summarize recent progress in aptamer selection and the application of aptamers in these targeted drug delivery systems but also discuss the advantages, challenges and new perspectives associated with these delivery systems.
KW - Aptamer
KW - Aptamer-functionalized targeted drug delivery systems
KW - Aptamer-nanomaterial conjugated systems
KW - Aptamer-small molecule conjugated systems
KW - SELEX
UR - http://www.scopus.com/inward/record.url?scp=84944056206&partnerID=8YFLogxK
U2 - 10.3390/ijms161023784
DO - 10.3390/ijms161023784
M3 - Journal article
C2 - 26473828
AN - SCOPUS:84944056206
SN - 1661-6596
VL - 16
SP - 23784
EP - 23822
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 10
ER -