Prodrug strategies for paclitaxel

Ziyuan Meng, Quanxia Lv, Jun Lu, Houzong Yao, Xiaoqing Lv, Feng Jiang*, Aiping LYU, Ge ZHANG

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)
1 Downloads (Pure)

Abstract

Paclitaxel is an anti-tumor agent with remarkable anti-tumor activity and wide clinical uses. However, it is also faced with various challenges especially for its poor water solubility and low selectivity for the target. To overcome these disadvantages of paclitaxel, approaches using small molecule modifications and macromolecule modifications have been developed by many research groups from all over the world. In this review, we discuss the different strategies especially prodrug strategies that are currently used to make paclitaxel more effective.

Original languageEnglish
Article number796
JournalInternational Journal of Molecular Sciences
Volume17
Issue number5
DOIs
Publication statusPublished - May 2016

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Low selectivity
  • Paclitaxel
  • Poor water solubility
  • Prodrug

Fingerprint

Dive into the research topics of 'Prodrug strategies for paclitaxel'. Together they form a unique fingerprint.

Cite this