TY - JOUR
T1 - Prior exercise training and experimental myocardial infarction
T2 - A systematic review and meta-analysis
AU - Veiga, Eduardo Carvalho de Arruda
AU - de Melo, Brunno Lemes
AU - Vieira, Stella de Souza
AU - Simões, Ricardo S.
AU - Valenti, Vitor E.
AU - Campos, Marcelo Ferraz
AU - Do Vale, Joseane Elza Tonussi Mendez Rossetti
AU - Rica, Roberta Lukesvicius
AU - Soares-Júnior, José Maria
AU - Baracat, Edmund Chada
AU - Serra, Andrey Jorge
AU - Baker, Julien
AU - Bocalini, Danilo Sales
N1 - Funding Information:
This study was supported by grants from FAPESP, FAPES, CNPq and CAPES. The authors thank CAPES and FAPES (590/ 19-no.84417625/2018).
PY - 2020/1/14
Y1 - 2020/1/14
N2 - Exercising prior to experimental infarction may have beneficial effects on the heart. The objective of this study was to analyze studies on animals that had exercised prior to myocardial infarction and to examine any benefits through a systematic review and meta-analysis. The databases MEDLINE, Google Scholar, and Cochrane were consulted. We analyzed articles published between January 1978 and November 2018. From a total of 858 articles, 13 manuscripts were selected in this review. When animals exercised before experimental infarction, there was a reduction in mortality, a reduction in infarct size, improvements in cardiac function, and a better molecular balance between genes and proteins that exhibit cardiac protective effects. Analyzing heart weight/body weight, we observed the following results-Mean difference 95% CI--0.02 [-0.61,0.57]. Meta-analysis of the infarct size (% of the left ventricle) revealed a statistically significant decrease in the size of the infarction in animals that exercised before myocardial infarction, in comparison with the sedentary animals-5.05 [-7.68,-2.40]. Analysis of the ejection fraction, measured by echo (%), revealed that animals that exercised before myocardial infarction exhibited higher and statistically significant measures, compared with sedentary animals 8.77 [3.87,13.66]. We conclude that exercise performed prior to experimental myocardial infarction confers cardiac benefits to animals.
AB - Exercising prior to experimental infarction may have beneficial effects on the heart. The objective of this study was to analyze studies on animals that had exercised prior to myocardial infarction and to examine any benefits through a systematic review and meta-analysis. The databases MEDLINE, Google Scholar, and Cochrane were consulted. We analyzed articles published between January 1978 and November 2018. From a total of 858 articles, 13 manuscripts were selected in this review. When animals exercised before experimental infarction, there was a reduction in mortality, a reduction in infarct size, improvements in cardiac function, and a better molecular balance between genes and proteins that exhibit cardiac protective effects. Analyzing heart weight/body weight, we observed the following results-Mean difference 95% CI--0.02 [-0.61,0.57]. Meta-analysis of the infarct size (% of the left ventricle) revealed a statistically significant decrease in the size of the infarction in animals that exercised before myocardial infarction, in comparison with the sedentary animals-5.05 [-7.68,-2.40]. Analysis of the ejection fraction, measured by echo (%), revealed that animals that exercised before myocardial infarction exhibited higher and statistically significant measures, compared with sedentary animals 8.77 [3.87,13.66]. We conclude that exercise performed prior to experimental myocardial infarction confers cardiac benefits to animals.
KW - Exercise Training
KW - Experimental Myocardial Infarctions
KW - Meta-Analysis
KW - Prior Exercise
KW - Running
KW - Swimming
KW - Systematic Reviews
UR - http://www.scopus.com/inward/record.url?scp=85078227640&partnerID=8YFLogxK
U2 - 10.6061/clinics/2020/e1293
DO - 10.6061/clinics/2020/e1293
M3 - Review article
C2 - 31967282
AN - SCOPUS:85078227640
SN - 1807-5932
VL - 75
JO - Clinics
JF - Clinics
M1 - e1293
ER -
