Present advances and future perspectives of molecular targeted therapy for osteosarcoma

Atik Badshah Shaikh; Fangfei Li; Min Li; Bing He; Xiaojuan He; Guofen Chen; Baosheng Guo; Defang Li; Feng Jiang; Lei Dang; Shaowei Zheng; Chao Liang; Jin Liu; Cheng Lu; Biao Liu; Jun Lu; Luyao Wang; Aiping Lyu; Ge Zhang

doi:10.3390/ijms17040506

Present advances and future perspectives of molecular targeted therapy for osteosarcoma

Atik Badshah Shaikh, Fangfei Li, Min Li, Bing He, Xiaojuan He, Guofen Chen, Baosheng Guo, Defang Li, Feng Jiang, Lei Dang, Shaowei Zheng, Chao Liang, Jin Liu, Cheng Lu, Biao Liu, Jun Lu, Luyao Wang, Aiping Lyu^*, Ge Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

105 Citations (Scopus)

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Abstract

Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%–75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken place. Hence, novel precise OS-targeting therapies are being developed with the hope of addressing this issue. This review summarizes the current development of molecular mechanisms and targets for osteosarcoma. Therapies that target these mechanisms with updated information on clinical trials are also reviewed. Meanwhile, we further discuss novel therapeutic targets and OS-targeting drug delivery systems. In conclusion, a full insight in OS pathogenesis and OS-targeting strategies would help us explore novel targeted therapies for metastatic osteosarcoma.

Original language	English
Article number	506
Number of pages	21
Journal	International Journal of Molecular Sciences
Volume	17
Issue number	4
DOIs	https://doi.org/10.3390/ijms17040506
Publication status	Published - 6 Apr 2016

Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

User-Defined Keywords

Molecular mechanism
Molecular targets
Osteosarcoma
Targeted therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms17040506

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Shaikh, A. B., Li, F., Li, M., He, B., He, X., Chen, G., Guo, B., Li, D., Jiang, F., Dang, L., Zheng, S., Liang, C., Liu, J., Lu, C., Liu, B., Lu, J., Wang, L., Lyu, A., & Zhang, G. (2016). Present advances and future perspectives of molecular targeted therapy for osteosarcoma. International Journal of Molecular Sciences, 17(4), Article 506. https://doi.org/10.3390/ijms17040506

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abstract = "Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%–75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken place. Hence, novel precise OS-targeting therapies are being developed with the hope of addressing this issue. This review summarizes the current development of molecular mechanisms and targets for osteosarcoma. Therapies that target these mechanisms with updated information on clinical trials are also reviewed. Meanwhile, we further discuss novel therapeutic targets and OS-targeting drug delivery systems. In conclusion, a full insight in OS pathogenesis and OS-targeting strategies would help us explore novel targeted therapies for metastatic osteosarcoma.",

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AU - Shaikh, Atik Badshah

AU - Li, Fangfei

AU - Li, Min

AU - He, Bing

AU - He, Xiaojuan

AU - Chen, Guofen

AU - Guo, Baosheng

AU - Li, Defang

AU - Jiang, Feng

AU - Dang, Lei

AU - Zheng, Shaowei

AU - Liang, Chao

AU - Liu, Jin

AU - Lu, Cheng

AU - Liu, Biao

AU - Lu, Jun

AU - Wang, Luyao

AU - Lyu, Aiping

AU - Zhang, Ge

PY - 2016/4/6

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N2 - Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%–75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken place. Hence, novel precise OS-targeting therapies are being developed with the hope of addressing this issue. This review summarizes the current development of molecular mechanisms and targets for osteosarcoma. Therapies that target these mechanisms with updated information on clinical trials are also reviewed. Meanwhile, we further discuss novel therapeutic targets and OS-targeting drug delivery systems. In conclusion, a full insight in OS pathogenesis and OS-targeting strategies would help us explore novel targeted therapies for metastatic osteosarcoma.

AB - Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%–75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken place. Hence, novel precise OS-targeting therapies are being developed with the hope of addressing this issue. This review summarizes the current development of molecular mechanisms and targets for osteosarcoma. Therapies that target these mechanisms with updated information on clinical trials are also reviewed. Meanwhile, we further discuss novel therapeutic targets and OS-targeting drug delivery systems. In conclusion, a full insight in OS pathogenesis and OS-targeting strategies would help us explore novel targeted therapies for metastatic osteosarcoma.

KW - Molecular mechanism

KW - Molecular targets

KW - Osteosarcoma

KW - Targeted therapy

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U2 - 10.3390/ijms17040506

DO - 10.3390/ijms17040506

M3 - Review article

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SN - 1661-6596

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

Present advances and future perspectives of molecular targeted therapy for osteosarcoma

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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