Preparation-related structural diversity and medical potential in the treatment of diabetes mellitus with ginseng pectins

Qilei Chen, Lin Zhu, Yina Tang, Zhongzhen ZHAO, Tao YI*, Hubiao CHEN

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

Pectins isolated from Panax ginseng C.A. Meyer are potential therapeutic agents for the treatment of diabetes mellitus, a global health challenge. Soil-to-bench procedures of ginseng pectin preparation significantly affect the polysaccharide structures. Various forms of ginseng pectins rich in homogalacturonan, rhamnogalacturonan-I, rhamnogalacturonan-II, and arabinogalactan have demonstrated independent or collaborative effects on hyperglycemia, oxidative stress, immunological dysfunction, and neoplasms. Monosaccharide compositions, peptide contents, degrees of esterification and methylation, and inter- and intramolecular linkages all influence pectin bioactivity. Understanding the preparation–structure and structure–function relationships of ginseng pectins can lead to safer and more pertinent treatment of diabetes with efficacy-oriented modifications of the pectins. To reach this goal, standardization of preparation procedures, understanding of intricate structures, and exploration of complex interactions with receptors are crucial steps to take full advantage of the medical potential of ginseng pectins.

Original languageEnglish
Pages (from-to)75-89
Number of pages15
JournalAnnals of the New York Academy of Sciences
Volume1401
Issue number1
DOIs
Publication statusPublished - 2017

Scopus Subject Areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

User-Defined Keywords

  • arabinogalactan
  • diabetes mellitus
  • ginseng pectin
  • homogalacturonan
  • rhamnogalacturonan

Fingerprint

Dive into the research topics of 'Preparation-related structural diversity and medical potential in the treatment of diabetes mellitus with ginseng pectins'. Together they form a unique fingerprint.

Cite this