Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

Kim Hung Lam; Kenneth Ka Ho Lee; Roberto Gambari; Raymond Siu Ming Wong; Gregory Yin Ming Cheng; See Wai Tong; Kit Wah Chan; Fung Yi Lau; Paul Bo San Lai; Wai Yeung Wong; Albert Sun Chi Chan; Stanton Hon Lung Kok; Johnny Cheuk On Tang; Chung Hin Chui

doi:10.1016/j.phymed.2012.09.026

Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

Kim Hung Lam
, Kenneth Ka Ho Lee
, Roberto Gambari
, Raymond Siu Ming Wong
, Gregory Yin Ming Cheng
, See Wai Tong
, Kit Wah Chan
, Fung Yi Lau
, Paul Bo San Lai
, Wai Yeung Wong^*
, Albert Sun Chi Chan
, Stanton Hon Lung Kok
, Johnny Cheuk On Tang
, Chung Hin Chui

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.

Original language	English
Pages (from-to)	166-171
Number of pages	6
Journal	Phytomedicine
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.phymed.2012.09.026
Publication status	Published - 15 Jan 2013

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Cancer cells
Galipea officinalis
Tetrahydroquinoline alkaloid
Xenograft

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10.1016/j.phymed.2012.09.026

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Lam, K. H., Lee, K. K. H., Gambari, R., Wong, R. S. M., Cheng, G. Y. M., Tong, S. W., Chan, K. W., Lau, F. Y., Lai, P. B. S., Wong, W. Y., Chan, A. S. C., Kok, S. H. L., Tang, J. C. O., & Chui, C. H. (2013). Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents. Phytomedicine, 20(2), 166-171. https://doi.org/10.1016/j.phymed.2012.09.026

@article{a1e2364da2ae4798a31993b93b238128,

title = "Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents",

abstract = "The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.",

keywords = "Cancer cells, Galipea officinalis, Tetrahydroquinoline alkaloid, Xenograft",

author = "Lam, \{Kim Hung\} and Lee, \{Kenneth Ka Ho\} and Roberto Gambari and Wong, \{Raymond Siu Ming\} and Cheng, \{Gregory Yin Ming\} and Tong, \{See Wai\} and Chan, \{Kit Wah\} and Lau, \{Fung Yi\} and Lai, \{Paul Bo San\} and Wong, \{Wai Yeung\} and Chan, \{Albert Sun Chi\} and Kok, \{Stanton Hon Lung\} and Tang, \{Johnny Cheuk On\} and Chui, \{Chung Hin\}",

note = "Funding Information: We acknowledge the financial support provided by the Hong Kong Polytechnic University to Dr. C.-H. Chui ( APL-80 ).",

year = "2013",

month = jan,

day = "15",

doi = "10.1016/j.phymed.2012.09.026",

language = "English",

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pages = "166--171",

journal = "Phytomedicine",

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T1 - Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

AU - Lam, Kim Hung

AU - Lee, Kenneth Ka Ho

AU - Gambari, Roberto

AU - Wong, Raymond Siu Ming

AU - Cheng, Gregory Yin Ming

AU - Tong, See Wai

AU - Chan, Kit Wah

AU - Lau, Fung Yi

AU - Lai, Paul Bo San

AU - Wong, Wai Yeung

AU - Chan, Albert Sun Chi

AU - Kok, Stanton Hon Lung

AU - Tang, Johnny Cheuk On

AU - Chui, Chung Hin

N1 - Funding Information: We acknowledge the financial support provided by the Hong Kong Polytechnic University to Dr. C.-H. Chui ( APL-80 ).

PY - 2013/1/15

Y1 - 2013/1/15

N2 - The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.

AB - The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.

KW - Cancer cells

KW - Galipea officinalis

KW - Tetrahydroquinoline alkaloid

KW - Xenograft

UR - https://www.scopus.com/pages/publications/84871719532

U2 - 10.1016/j.phymed.2012.09.026

DO - 10.1016/j.phymed.2012.09.026

M3 - Journal article

C2 - 23123223

AN - SCOPUS:84871719532

SN - 0944-7113

VL - 20

SP - 166

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JO - Phytomedicine

JF - Phytomedicine

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ER -

Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

Abstract

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