Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

Kim Hung Lam; Kenneth Ka Ho Lee; Roberto Gambari; Raymond Siu Ming Wong; Gregory Yin Ming Cheng; See Wai Tong; Kit Wah Chan; Fung Yi Lau; Paul Bo San Lai; Wai Yeung Wong; Albert Sun Chi Chan; Stanton Hon Lung Kok; Johnny Cheuk On Tang; Chung Hin Chui

doi:10.1016/j.phymed.2012.09.026

Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

Kim Hung Lam, Kenneth Ka Ho Lee, Roberto Gambari, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, See Wai Tong, Kit Wah Chan, Fung Yi Lau, Paul Bo San Lai, Wai Yeung Wong^*, Albert Sun Chi Chan, Stanton Hon Lung Kok, Johnny Cheuk On Tang, Chung Hin Chui

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

13 Citations (Scopus)

Abstract

The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.

Original language	English
Pages (from-to)	166-171
Number of pages	6
Journal	Phytomedicine
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.phymed.2012.09.026
Publication status	Published - 15 Jan 2013

Scopus Subject Areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

User-Defined Keywords

Cancer cells
Galipea officinalis
Tetrahydroquinoline alkaloid
Xenograft

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phymed.2012.09.026

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Lam, K. H., Lee, K. K. H., Gambari, R., Wong, R. S. M., Cheng, G. Y. M., Tong, S. W., Chan, K. W., Lau, F. Y., Lai, P. B. S., Wong, W. Y., Chan, A. S. C., Kok, S. H. L., Tang, J. C. O., & Chui, C. H. (2013). Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents. Phytomedicine, 20(2), 166-171. https://doi.org/10.1016/j.phymed.2012.09.026

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title = "Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents",

abstract = "The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.",

keywords = "Cancer cells, Galipea officinalis, Tetrahydroquinoline alkaloid, Xenograft",

author = "Lam, {Kim Hung} and Lee, {Kenneth Ka Ho} and Roberto Gambari and Wong, {Raymond Siu Ming} and Cheng, {Gregory Yin Ming} and Tong, {See Wai} and Chan, {Kit Wah} and Lau, {Fung Yi} and Lai, {Paul Bo San} and Wong, {Wai Yeung} and Chan, {Albert Sun Chi} and Kok, {Stanton Hon Lung} and Tang, {Johnny Cheuk On} and Chui, {Chung Hin}",

note = "Funding Information: We acknowledge the financial support provided by the Hong Kong Polytechnic University to Dr. C.-H. Chui ( APL-80 ).",

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doi = "10.1016/j.phymed.2012.09.026",

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AU - Lam, Kim Hung

AU - Lee, Kenneth Ka Ho

AU - Gambari, Roberto

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AU - Cheng, Gregory Yin Ming

AU - Tong, See Wai

AU - Chan, Kit Wah

AU - Lau, Fung Yi

AU - Lai, Paul Bo San

AU - Wong, Wai Yeung

AU - Chan, Albert Sun Chi

AU - Kok, Stanton Hon Lung

AU - Tang, Johnny Cheuk On

AU - Chui, Chung Hin

N1 - Funding Information: We acknowledge the financial support provided by the Hong Kong Polytechnic University to Dr. C.-H. Chui ( APL-80 ).

PY - 2013/1/15

Y1 - 2013/1/15

N2 - The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.

AB - The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.

KW - Cancer cells

KW - Galipea officinalis

KW - Tetrahydroquinoline alkaloid

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Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

Abstract

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