Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents

Kim Hung Lam, Kenneth Ka Ho Lee, Roberto Gambari, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, See Wai Tong, Kit Wah Chan, Fung Yi Lau, Paul Bo San Lai, Wai Yeung WONG*, Albert Sun Chi Chan, Stanton Hon Lung Kok, Johnny Cheuk On Tang, Chung Hin CHUI

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The preparation of chiral tetrahydroquinolines using Ir-catalysed asymmetric hydrogenation and their possible cytotoxic potential anti-cancer activity were reported. Both of the in vitro cytotoxicity assay on a series of human cancer cell lines including A549 small cell lung cancer, MDA-MB-231 breast cancer, SaoS2 sacroma, SKHep-1 hepatoma and Hep3B hepatocellular carcinoma as well as in vivo animal model using Hep3B hepatocellular tumour xenograft on athymic nude mice suggest that 1,2,3,4-tetrahydroquin-8-ol is a potential anti-tumour alkaloid which may be further developed as a novel cancer chemotherapeutic agent.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalPhytomedicine
Volume20
Issue number2
DOIs
Publication statusPublished - 15 Jan 2013

Scopus Subject Areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

User-Defined Keywords

  • Cancer cells
  • Galipea officinalis
  • Tetrahydroquinoline alkaloid
  • Xenograft

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