Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Kim Hung Lam; Roberto Gambari; Kenneth Ka Ho Lee; Yi Xin Chen; Stanton Hon Lung Kok; Raymond Siu Ming Wong; Fung Yi Lau; Chor Hing Cheng; Wai Yeung WONG; Zhaoxiang BIAN; Albert Sun Chi Chan; Johnny Cheuk On Tang; Chung Hin CHUI

doi:10.1016/j.bmcl.2013.10.072

Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Kim Hung Lam^*
, Roberto Gambari
, Kenneth Ka Ho Lee
, Yi Xin Chen
, Stanton Hon Lung Kok
, Raymond Siu Ming Wong
, Fung Yi Lau
, Chor Hing Cheng
, Wai Yeung WONG
, Zhaoxiang BIAN
, Albert Sun Chi Chan
, Johnny Cheuk On Tang
, Chung Hin CHUI

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

50 Citations (Scopus)

Abstract

This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.

Original language	English
Pages (from-to)	367-370
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2013.10.072
Publication status	Published - 1 Jan 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Antibacterial agents
Antibiotics
Quinolines
Staphylococcus aureus

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10.1016/j.bmcl.2013.10.072

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Lam, K. H., Gambari, R., Lee, K. K. H., Chen, Y. X., Kok, S. H. L., Wong, R. S. M., Lau, F. Y., Cheng, C. H., WONG, W. Y., BIAN, Z., Chan, A. S. C., Tang, J. C. O., & CHUI, C. H. (2014). Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus. Bioorganic and Medicinal Chemistry Letters, 24(1), 367-370. https://doi.org/10.1016/j.bmcl.2013.10.072

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title = "Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus",

abstract = "This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.",

keywords = "Antibacterial agents, Antibiotics, Quinolines, Staphylococcus aureus",

author = "Lam, \{Kim Hung\} and Roberto Gambari and Lee, \{Kenneth Ka Ho\} and Chen, \{Yi Xin\} and Kok, \{Stanton Hon Lung\} and Wong, \{Raymond Siu Ming\} and Lau, \{Fung Yi\} and Cheng, \{Chor Hing\} and WONG, \{Wai Yeung\} and Zhaoxiang BIAN and Chan, \{Albert Sun Chi\} and Tang, \{Johnny Cheuk On\} and CHUI, \{Chung Hin\}",

note = "Funding Information: Dr. C.-H. Chui acknowledges the start-up research fund (38-40-116) from Hong Kong Baptist University. The authors also thank the financial support from Professor K.K.-H. Lee (Chinese University of Hong Kong), Professor X.-Z. Bian (03-16-176, Hong Kong Baptist University) and a research grant from Research Grant Committee, Innovation Technology Commission and Hong Kong Polytechnic University. Dr. J.C.-O. Tang acknowledges the internal grant from Hong Kong Polytechnic University (G-YM35) and Dr. P. Chan who provided the compounds for the biological experiments.",

year = "2014",

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doi = "10.1016/j.bmcl.2013.10.072",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

AU - Lam, Kim Hung

AU - Gambari, Roberto

AU - Lee, Kenneth Ka Ho

AU - Chen, Yi Xin

AU - Kok, Stanton Hon Lung

AU - Wong, Raymond Siu Ming

AU - Lau, Fung Yi

AU - Cheng, Chor Hing

AU - WONG, Wai Yeung

AU - BIAN, Zhaoxiang

AU - Chan, Albert Sun Chi

AU - Tang, Johnny Cheuk On

AU - CHUI, Chung Hin

N1 - Funding Information: Dr. C.-H. Chui acknowledges the start-up research fund (38-40-116) from Hong Kong Baptist University. The authors also thank the financial support from Professor K.K.-H. Lee (Chinese University of Hong Kong), Professor X.-Z. Bian (03-16-176, Hong Kong Baptist University) and a research grant from Research Grant Committee, Innovation Technology Commission and Hong Kong Polytechnic University. Dr. J.C.-O. Tang acknowledges the internal grant from Hong Kong Polytechnic University (G-YM35) and Dr. P. Chan who provided the compounds for the biological experiments.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.

AB - This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.

KW - Antibacterial agents

KW - Antibiotics

KW - Quinolines

KW - Staphylococcus aureus

UR - https://www.scopus.com/pages/publications/84891419911

U2 - 10.1016/j.bmcl.2013.10.072

DO - 10.1016/j.bmcl.2013.10.072

M3 - Journal article

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AN - SCOPUS:84891419911

SN - 0960-894X

VL - 24

SP - 367

EP - 370

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

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