Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

Kim Hung Lam*, Roberto Gambari, Kenneth Ka Ho Lee, Yi Xin Chen, Stanton Hon Lung Kok, Raymond Siu Ming Wong, Fung Yi Lau, Chor Hing Cheng, Wai Yeung WONG, Zhaoxiang BIAN, Albert Sun Chi Chan, Johnny Cheuk On Tang, Chung Hin CHUI

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

45 Citations (Scopus)


This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
Publication statusPublished - 1 Jan 2014

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

User-Defined Keywords

  • Antibacterial agents
  • Antibiotics
  • Quinolines
  • Staphylococcus aureus


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