Prenatal exposure to bisphenol A and its alternatives and child neurodevelopment at 2 years

Yangqian Jiang, Jiufeng Li, Shunqing Xu, Yanqiu Zhou, Hongzhi Zhao, Yuanyuan Li, Chao Xiong, Xiaojie Sun, Hongxiu Liu, Wenyu Liu, Yang Peng, Chen Hu, Zongwei CAI*, Wei Xia*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

66 Citations (Scopus)


While increasing evidence has shown that prenatal bisphenol A (BPA) exposure is adversely associated with child neurodevelopment, little is known about the neurodevelopmental effects of BPA alternatives, such as bisphenol S (BPS) and bisphenol F (BPF). We aimed to evaluate the relationships of repeated measurements of bisphenol exposure during pregnancy with child neurodevelopment. From 2014–2015, 456 mother-child pairs were included in the present study. Each had a spot urine sample in the first, second, and third trimester, respectively, during pregnancy for BPA, BPS, and BPF measurements. Children's neurodevelopment was assessed using the Bayley Scales of Infant Development at 2 years. In adjusted models, children's psychomotor development index scores decreased across quartiles of BPS concentrations [-5.52 (95 % CI: -10.06, -0.99) in the 4th quartile vs. 1 st quartile, P-trend = 0.01]. Each 10-fold increase in BPA concentrations was related to lower mental development index scores only in the second trimester [-2.87 (95 % CI: -4.98, -0.75), Ptrimester-int = 0.04]. However, prenatal BPF exposure was not significantly associated with child neurodevelopment. We provide evidence that prenatal exposure to BPA and BPS may affect child neurodevelopment.

Original languageEnglish
Article number121774
JournalJournal of Hazardous Materials
Publication statusPublished - 15 Apr 2020

Scopus Subject Areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis

User-Defined Keywords

  • Bisphenol A
  • Bisphenol F
  • Bisphenol S
  • Child neurodevelopment


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