TY - JOUR
T1 - Prenatal exposure to benzotraizoles and benzothiazoles in relation to fetal and birth size
T2 - A longitudinal study
AU - Zhou, Yanqiu
AU - Li, Ying
AU - Xu, Shunqing
AU - Liao, Jiaqiang
AU - Zhang, Hongna
AU - Li, Jiufeng
AU - HONG, Yanjun
AU - Xia, Wei
AU - Cai, Zongwei
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China (21437002) and Collaborative Research Fund (C2014?14E) from Research Grants Council of Hong Kong.
Funding Information:
This work was supported by National Natural Science Foundation of China ( 21437002 ) and Collaborative Research Fund (C2014−14E) from Research Grants Council of Hong Kong.
PY - 2020/11/5
Y1 - 2020/11/5
N2 - The presence of benzotriazoles and benzothiazoles (BTs) in maternal urine and amniotic fluid indicated the widespread fetal exposure to the contaminants. We investigated the associations of prenatal BTs exposure with fetal and birth size and explored the window of susceptibility. Participants consisted of 856 mother-infant pairs drawn from a prospective birth cohort between 2014 and 2015 in Wuhan, China. Prenatal BTs exposure were measured in multiple urine samples collected across three trimesters. We observed positive associations between prenatal exposure to specific BTs (e.g., 1-H-benzotriazole, 1-hydroxy-benzotriazole and 2-amino-benzothiazole) and femur length (FL) and birth length z-scores among girls. In boys, a 2-fold increase of averaged concentration of urinary benzothiazole (BTH) was associated with decrement in FL (β = -0.068, p < 0.001) and birth length (β = -0.055, p = 0.005) z-scores. Further analysis indicated that the negative associations between urinary concentrations of BTH and birth length z-score among boys were observed at exposure measurement in 25–35 gestational weeks. This study reported the associations between prenatal exposure to BTs and fetal and birth size, suggests the associations maybe in a sex-specific manner and the window of exposure may influence susceptibility. These findings require replication in future research.
AB - The presence of benzotriazoles and benzothiazoles (BTs) in maternal urine and amniotic fluid indicated the widespread fetal exposure to the contaminants. We investigated the associations of prenatal BTs exposure with fetal and birth size and explored the window of susceptibility. Participants consisted of 856 mother-infant pairs drawn from a prospective birth cohort between 2014 and 2015 in Wuhan, China. Prenatal BTs exposure were measured in multiple urine samples collected across three trimesters. We observed positive associations between prenatal exposure to specific BTs (e.g., 1-H-benzotriazole, 1-hydroxy-benzotriazole and 2-amino-benzothiazole) and femur length (FL) and birth length z-scores among girls. In boys, a 2-fold increase of averaged concentration of urinary benzothiazole (BTH) was associated with decrement in FL (β = -0.068, p < 0.001) and birth length (β = -0.055, p = 0.005) z-scores. Further analysis indicated that the negative associations between urinary concentrations of BTH and birth length z-score among boys were observed at exposure measurement in 25–35 gestational weeks. This study reported the associations between prenatal exposure to BTs and fetal and birth size, suggests the associations maybe in a sex-specific manner and the window of exposure may influence susceptibility. These findings require replication in future research.
KW - Benzothiazole
KW - Benzotriazole
KW - Fetal and birth size
KW - Longitudinal
UR - http://www.scopus.com/inward/record.url?scp=85085874975&partnerID=8YFLogxK
U2 - 10.1016/j.jhazmat.2020.122828
DO - 10.1016/j.jhazmat.2020.122828
M3 - Journal article
C2 - 32512437
AN - SCOPUS:85085874975
SN - 0304-3894
VL - 398
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
M1 - 122828
ER -