TY - JOUR
T1 - Predictive Ability of Hypertriglyceridemic Waist, Hypertriglyceridemic Waist-to-Height Ratio, and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents
AU - XIAO, Tian Li
AU - YUAN, Shu Qian
AU - GAO, Jing Yu
AU - Baker, Julien S.
AU - YANG, Yi De
AU - WANG, Xi Jie
AU - ZHENG, Chan Juan
AU - DONG, Yan Hui
AU - ZOU, Zhi Yong
N1 - This study was supported by the National Natural Science Foundation of China [no. 81903336, Yi-de Yang]; the Health Research Project of Hunan Provincial Health Commission [no. 202112031516, Yi-de Yang]; Scientific Research Fund of Hunan Provincial Education Department [no. 22B0038, Yi-de Yang]; the Research Team for Reproduction Health and Translational Medicine of Hunan Normal University [2023JC101]; Key Project of Developmental Biology and Breeding from Hunan Province [no. 2022XKQ0205]; and Open Project for Postgraduates of Hunan Normal University [no. KF2022019, Tianli Xiao].
Publisher Copyright:
© 2024 The Editorial Board of Biomedical and Environmental Sciences
PY - 2024/4
Y1 - 2024/4
N2 - Objective: Hypertriglyceridemic waist (HW), hypertriglyceridemic waist-to-height ratio (HWHtR), and waist-to-hip ratio (WHR) have been shown to be indicators of cardiometabolic risk factors. However, it is not clear which indicator is more suitable for children and adolescents. We aimed to investigate the relationship between HW, HWHtR, WHR, and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and adolescents.Methods: This was a national cross-sectional study. Anthropometric and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in China. Demographics, physical activity, dietary intake, and family history of chronic diseases were obtained through questionnaires. ANOVA, χ2 and logistic regression analysis was conducted. Results: A significant sex difference was observed for HWHtR and WHR, but not for HW phenotype. The risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents (HW: OR = 12.22, 95% CI: 9.54-15.67; HWHtR: OR = 9.70, 95% CI: 6.93-13.58). Compared with the HW and HWHtR phenotypes, the association between risk of cardiometabolic health risk factors (CHRF) clustering and high WHR was much weaker and not significant (WHR: OR = 1.14, 95% CI: 0.97-1.34).Conclusion: Compared with HWHtR and WHR, the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.
AB - Objective: Hypertriglyceridemic waist (HW), hypertriglyceridemic waist-to-height ratio (HWHtR), and waist-to-hip ratio (WHR) have been shown to be indicators of cardiometabolic risk factors. However, it is not clear which indicator is more suitable for children and adolescents. We aimed to investigate the relationship between HW, HWHtR, WHR, and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and adolescents.Methods: This was a national cross-sectional study. Anthropometric and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in China. Demographics, physical activity, dietary intake, and family history of chronic diseases were obtained through questionnaires. ANOVA, χ2 and logistic regression analysis was conducted. Results: A significant sex difference was observed for HWHtR and WHR, but not for HW phenotype. The risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents (HW: OR = 12.22, 95% CI: 9.54-15.67; HWHtR: OR = 9.70, 95% CI: 6.93-13.58). Compared with the HW and HWHtR phenotypes, the association between risk of cardiometabolic health risk factors (CHRF) clustering and high WHR was much weaker and not significant (WHR: OR = 1.14, 95% CI: 0.97-1.34).Conclusion: Compared with HWHtR and WHR, the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.
KW - Cardiovascular risk factors
KW - Children and adolescents
KW - China
KW - Hypertriglyceridemic waist
KW - Hypertriglyceridemic waist-to-height ratio
KW - Waist-to-hip ratio
UR - http://www.scopus.com/inward/record.url?scp=85190074744&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S0895398824000473
U2 - 10.3967/bes2024.027
DO - 10.3967/bes2024.027
M3 - Journal article
C2 - 38582988
AN - SCOPUS:85190074744
SN - 0895-3988
VL - 37
SP - 233
EP - 241
JO - Biomedical and Environmental Sciences
JF - Biomedical and Environmental Sciences
IS - 3
ER -