Predictive Ability of Hypertriglyceridemic Waist, Hypertriglyceridemic Waist-to-Height Ratio, and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

Tian Li XIAO, Shu Qian YUAN, Jing Yu GAO, Julien S. Baker, Yi De YANG*, Xi Jie WANG*, Chan Juan ZHENG, Yan Hui DONG, Zhi Yong ZOU*

*Corresponding author for this work

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    Objective: Hypertriglyceridemic waist (HW), hypertriglyceridemic waist-to-height ratio (HWHtR), and waist-to-hip ratio (WHR) have been shown to be indicators of cardiometabolic risk factors. However, it is not clear which indicator is more suitable for children and adolescents. We aimed to investigate the relationship between HW, HWHtR, WHR, and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and adolescents.

    Methods: This was a national cross-sectional study. Anthropometric and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in China. Demographics, physical activity, dietary intake, and family history of chronic diseases were obtained through questionnaires. ANOVA, χ2 and logistic regression analysis was conducted. 

    Results: A significant sex difference was observed for HWHtR and WHR, but not for HW phenotype. The risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents (HW: OR = 12.22, 95% CI: 9.54-15.67; HWHtR: OR = 9.70, 95% CI: 6.93-13.58). Compared with the HW and HWHtR phenotypes, the association between risk of cardiometabolic health risk factors (CHRF) clustering and high WHR was much weaker and not significant (WHR: OR = 1.14, 95% CI: 0.97-1.34).

    Conclusion: Compared with HWHtR and WHR, the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

    Original languageEnglish
    Pages (from-to)233-241
    Number of pages9
    JournalBiomedical and Environmental Sciences
    Volume37
    Issue number3
    DOIs
    Publication statusPublished - Apr 2024

    Scopus Subject Areas

    • Public Health, Environmental and Occupational Health
    • Health, Toxicology and Mutagenesis

    User-Defined Keywords

    • Cardiovascular risk factors
    • Children and adolescents
    • China
    • Hypertriglyceridemic waist
    • Hypertriglyceridemic waist-to-height ratio
    • Waist-to-hip ratio

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