Post-translational Regulation of BRI1-EMS Suppressor 1 and Brassinazole-resistant 1

Juan Mao; Biaodi Shen; Wenxin Li; Linchuan Liu; Jianming Li

doi:10.1093/pcp/pcae066

Post-translational Regulation of BRI1-EMS Suppressor 1 and Brassinazole-resistant 1

Juan Mao, Biaodi Shen, Wenxin Li, Linchuan Liu^*, Jianming Li^*

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

Brassinosteroid-insensitive 1 (BRI1)-EMS suppressor 1 (BES1) and Brassinazole-resistant 1 (BZR1) are two highly similar master transcription factors of the brassinosteroid (BR) signaling pathway that regulates a variety of plant growth and development processes as well as stress responses. Previous genetic and biochemical analyses have established a complex regulatory network to control the two transcription factors. This network includes coordination with other transcription factors and interactors, multiple post-translational modifications (PTMs) and differential subcellular localizations. In this review, we systematically detail the functions and regulatory mechanisms of various PTMs: phosphorylation/dephosphorylation, ubiquitination/deubiquitination, SUMOylation/deSUMOylation and oxidation/reduction, in regulating the subcellular localization, protein stability and the transcriptional activity of BES1/BZR1. We also discuss the current knowledge about the BES1/BZR1 interactors mediating the dynamic nucleocytoplasmic shuttling of BES1 and BZR1.

Original language	English
Pages (from-to)	1544–1551
Number of pages	8
Journal	Plant and Cell Physiology
Volume	65
Issue number	10
Early online date	19 Jun 2024
DOIs	https://doi.org/10.1093/pcp/pcae066
Publication status	Published - Oct 2024

User-Defined Keywords

BES1
BZR1
Brassinosteroids
Post-translational regulation

Access to Document

10.1093/pcp/pcae066

Cite this

@article{aa8955f63e10478b9dcfb5fd05b82b53,

title = "Post-translational Regulation of BRI1-EMS Suppressor 1 and Brassinazole-resistant 1",

abstract = "Brassinosteroid-insensitive 1 (BRI1)-EMS suppressor 1 (BES1) and Brassinazole-resistant 1 (BZR1) are two highly similar master transcription factors of the brassinosteroid (BR) signaling pathway that regulates a variety of plant growth and development processes as well as stress responses. Previous genetic and biochemical analyses have established a complex regulatory network to control the two transcription factors. This network includes coordination with other transcription factors and interactors, multiple post-translational modifications (PTMs) and differential subcellular localizations. In this review, we systematically detail the functions and regulatory mechanisms of various PTMs: phosphorylation/dephosphorylation, ubiquitination/deubiquitination, SUMOylation/deSUMOylation and oxidation/reduction, in regulating the subcellular localization, protein stability and the transcriptional activity of BES1/BZR1. We also discuss the current knowledge about the BES1/BZR1 interactors mediating the dynamic nucleocytoplasmic shuttling of BES1 and BZR1.",

keywords = "BES1, BZR1, Brassinosteroids, Post-translational regulation",

author = "Juan Mao and Biaodi Shen and Wenxin Li and Linchuan Liu and Jianming Li",

note = "This work was supported by the National Natural Science Foundation of China (No. 31900176 to Juan Mao, No. 31870253 to Jianming Li, and No. 31970187 to Linchuan Liu) and the Guangdong Basic and Applied Research Foundation (2020A1515011387 to Juan Mao and 2022A1515010803 to Linchuan Liu).",

year = "2024",

month = oct,

doi = "10.1093/pcp/pcae066",

language = "English",

volume = "65",

pages = "1544–1551",

journal = "Plant and Cell Physiology",

issn = "0032-0781",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Post-translational Regulation of BRI1-EMS Suppressor 1 and Brassinazole-resistant 1

AU - Mao, Juan

AU - Shen, Biaodi

AU - Li, Wenxin

AU - Liu, Linchuan

AU - Li, Jianming

N1 - This work was supported by the National Natural Science Foundation of China (No. 31900176 to Juan Mao, No. 31870253 to Jianming Li, and No. 31970187 to Linchuan Liu) and the Guangdong Basic and Applied Research Foundation (2020A1515011387 to Juan Mao and 2022A1515010803 to Linchuan Liu).

PY - 2024/10

Y1 - 2024/10

N2 - Brassinosteroid-insensitive 1 (BRI1)-EMS suppressor 1 (BES1) and Brassinazole-resistant 1 (BZR1) are two highly similar master transcription factors of the brassinosteroid (BR) signaling pathway that regulates a variety of plant growth and development processes as well as stress responses. Previous genetic and biochemical analyses have established a complex regulatory network to control the two transcription factors. This network includes coordination with other transcription factors and interactors, multiple post-translational modifications (PTMs) and differential subcellular localizations. In this review, we systematically detail the functions and regulatory mechanisms of various PTMs: phosphorylation/dephosphorylation, ubiquitination/deubiquitination, SUMOylation/deSUMOylation and oxidation/reduction, in regulating the subcellular localization, protein stability and the transcriptional activity of BES1/BZR1. We also discuss the current knowledge about the BES1/BZR1 interactors mediating the dynamic nucleocytoplasmic shuttling of BES1 and BZR1.

AB - Brassinosteroid-insensitive 1 (BRI1)-EMS suppressor 1 (BES1) and Brassinazole-resistant 1 (BZR1) are two highly similar master transcription factors of the brassinosteroid (BR) signaling pathway that regulates a variety of plant growth and development processes as well as stress responses. Previous genetic and biochemical analyses have established a complex regulatory network to control the two transcription factors. This network includes coordination with other transcription factors and interactors, multiple post-translational modifications (PTMs) and differential subcellular localizations. In this review, we systematically detail the functions and regulatory mechanisms of various PTMs: phosphorylation/dephosphorylation, ubiquitination/deubiquitination, SUMOylation/deSUMOylation and oxidation/reduction, in regulating the subcellular localization, protein stability and the transcriptional activity of BES1/BZR1. We also discuss the current knowledge about the BES1/BZR1 interactors mediating the dynamic nucleocytoplasmic shuttling of BES1 and BZR1.

KW - BES1

KW - BZR1

KW - Brassinosteroids

KW - Post-translational regulation

UR - http://www.scopus.com/inward/record.url?scp=85209156240&partnerID=8YFLogxK

U2 - 10.1093/pcp/pcae066

DO - 10.1093/pcp/pcae066

M3 - Journal article

SN - 0032-0781

VL - 65

SP - 1544

EP - 1551

JO - Plant and Cell Physiology

JF - Plant and Cell Physiology

IS - 10

ER -

Post-translational Regulation of BRI1-EMS Suppressor 1 and Brassinazole-resistant 1

Abstract

User-Defined Keywords

Access to Document

Other files and links

Fingerprint

Cite this