Post-translational Modifications of Key Machinery in the Control of Mitophagy

Liming Wang, Hao Qi, Yancheng Tang, Han-Ming Shen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Citations (Scopus)

Abstract

Mitophagy refers to the process of selective removal of damaged or superfluous mitochondria via the autophagy/lysosome pathway. In the past decade the molecular mechanisms underlying mitophagy have been extensively studied. It is now well established that the key mitophagy machinery undergoes extensive post-translational modifications (PTMs) such as phosphorylation/dephosphorylation, ubiquitination/deubiquitination, and acetylation/deacetylation that involve an array of enzymes including protein kinases/phosphatases, E3 ligases/deubiquitinases, acetyltransferases/deacetylases. In this review we provide a systematic summary of these key PTMs, and discuss the effectors and the functional implications of such PTMs in mitophagy-related diseases. Understanding PTM of the mitophagy machinery offers a unique window of opportunity for the discovery of novel mitophagy interventional strategies and for the control of mitophagy-related diseases.

Original languageEnglish
Pages (from-to)58-75
Number of pages18
JournalTrends in Biochemical Sciences
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 2020

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology

User-Defined Keywords

  • autophagy
  • mitophagy
  • Parkin
  • PINK1
  • PTMs
  • ubiquitin

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