Polysaccharides of dendrobium officinale induce aquaporin 5 translocation by activating M3 muscarinic receptors

Xiang Lin, Jing Yi Liu, Wing Yan Chung, Stephen Cho Wing Sze, Hai Yan Li, Li Xing Lao, Yan Bo Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Dendrobium officinale is an herbal medicine that has been clinically used to promote body fluid production. Previous works demonstrated that D. officinale polysaccharides could ameliorate symptoms of salivary secretion of patients with Sjögrenʼs syndrome and in a respective mice model. In the present study, we investigated the underlying mechanism by which D. officinale polysaccharides activate M3 muscarinic receptors and induce extracellular calcium influx, leading to the translocation of aquaporin 5, a water channel protein, to the apical membrane of human submandibular gland epithelial cells. Enzymatic treatment of D. officinale polysaccharides suggested that they are hydrolyzed but do not permeate cell membranes. This finding supports the pharmacological activity of D. officinale polysaccharides to promote salivary secretion.
Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalPlanta Medica
Volume81
Issue number2
Early online date15 Jan 2015
DOIs
Publication statusPublished - Jan 2015
Externally publishedYes

Scopus Subject Areas

  • Medicine(all)

User-Defined Keywords

  • Dendrobium officinale
  • Orchidaceae
  • polysaccharides
  • M3 muscarinic receptor
  • aquaporin 5

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