Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells

Quan Bing Han; Hong Lei Tian; Nian Yun Yang; Chun Feng Qiao; Jing Zheng Song; Donald S. Chang; Kathy Q. Luo; Hong Xi Xu

doi:10.1002/cbdv.200890225

Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells

Quan Bing Han, Hong Lei Tian, Nian Yun Yang, Chun Feng Qiao, Jing Zheng Song, Donald S. Chang, Kathy Q. Luo, Hong Xi Xu^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

35 Citations (Scopus)

Abstract

Three new prenylated xanthones, 1–3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.

Original language	English
Pages (from-to)	2710-2717
Number of pages	8
Journal	Chemistry and Biodiversity
Volume	5
Issue number	12
DOIs	https://doi.org/10.1002/cbdv.200890225
Publication status	Published - 16 Dec 2008

Scopus Subject Areas

Bioengineering
Biochemistry
General Chemistry
Molecular Medicine
Molecular Biology

User-Defined Keywords

Garcinia lancilimba
Xanthones
Apoptotic effect
Growth-inhibition activity

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10.1002/cbdv.200890225

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title = "Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells",

abstract = "Three new prenylated xanthones, 1–3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.",

keywords = "Garcinia lancilimba, Xanthones, Apoptotic effect, Growth-inhibition activity",

author = "Han, {Quan Bing} and Tian, {Hong Lei} and Yang, {Nian Yun} and Qiao, {Chun Feng} and Song, {Jing Zheng} and Chang, {Donald S.} and Luo, {Kathy Q.} and Xu, {Hong Xi}",

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doi = "10.1002/cbdv.200890225",

language = "English",

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T1 - Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells

AU - Han, Quan Bing

AU - Tian, Hong Lei

AU - Yang, Nian Yun

AU - Qiao, Chun Feng

AU - Song, Jing Zheng

AU - Chang, Donald S.

AU - Luo, Kathy Q.

AU - Xu, Hong Xi

PY - 2008/12/16

Y1 - 2008/12/16

N2 - Three new prenylated xanthones, 1–3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.

AB - Three new prenylated xanthones, 1–3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.

KW - Garcinia lancilimba

KW - Xanthones

KW - Apoptotic effect

KW - Growth-inhibition activity

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U2 - 10.1002/cbdv.200890225

DO - 10.1002/cbdv.200890225

M3 - Journal article

SN - 1612-1872

VL - 5

SP - 2710

EP - 2717

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 12

ER -

Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells

Abstract

Scopus Subject Areas

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