Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study

D Cugino; F Gianfagna; W Ahrens; S De Henauw; A C Koni; S Marild; D Molnar; L A Moreno; Y Pitsiladis; P Russo; A Siani; M Tornaritis; T Veidebaum; L Iacoviello

doi:10.1038/ijo.2013.21

Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study

D Cugino, F Gianfagna, W Ahrens, S De Henauw, A C Koni, S Marild, D Molnar, L A Moreno, Y Pitsiladis, P Russo, A Siani, M Tornaritis, T Veidebaum, L Iacoviello^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

7 Citations (Scopus)

Abstract

Objective: We investigated the relationship between matrix metalloproteinase 3 (MMP3) polymorphisms and adiposity indices in European children of the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants) project.

Subjects: A total of 16 224 Caucasian children (2–9 years) were recruited into a population-based survey from eight European countries. In all, 4540 children were randomly selected for genetic studies (T0); 3238 children were re-examined 2 years later (T1). Anthropometric measures were collected by standardized protocols at T0 and T1.

Results: Six variants of MMP3 gene were genotyped. Homozygotes for the variant A allele of rs646910 and for the H3 haplotype had higher hip circumference (P=0.002 and 0.001; age, sex and country adjusted) at T0. The association remained significant after false discovery rate (FDR) correction. At T1, subjects carrying rs646910 A/A genotype or H3/H3 diplotype showed significantly higher values of body mass index, waist and hip circumference and sum of tricipital and subscapular skinfolds, all associations remaining significant after FDR correction (P=0.020–0.048).

Conclusions: We showed for the first time an association between the MMP3 rs646910 variant and indices of adiposity in European children, highlighting the involvement of metalloproteinase genes in adipose tissue remodeling and growth.

Original language	English
Pages (from-to)	1539-1544
Number of pages	6
Journal	International Journal of Obesity
Volume	37
Issue number	12
DOIs	https://doi.org/10.1038/ijo.2013.21
Publication status	Published - Dec 2013

Scopus Subject Areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

User-Defined Keywords

cardiovascular risk
children
matrix metalloproteinase
prospective study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ijo.2013.21

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Cugino, D., Gianfagna, F., Ahrens, W., De Henauw, S., Koni, A. C., Marild, S., Molnar, D., Moreno, L. A., Pitsiladis, Y., Russo, P., Siani, A., Tornaritis, M., Veidebaum, T., & Iacoviello, L. (2013). Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study. International Journal of Obesity, 37(12), 1539-1544. https://doi.org/10.1038/ijo.2013.21

@article{c07c1a982ed04979984378a5d93232c7,

title = "Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study",

abstract = "Objective: We investigated the relationship between matrix metalloproteinase 3 (MMP3) polymorphisms and adiposity indices in European children of the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants) project.Subjects: A total of 16 224 Caucasian children (2–9 years) were recruited into a population-based survey from eight European countries. In all, 4540 children were randomly selected for genetic studies (T0); 3238 children were re-examined 2 years later (T1). Anthropometric measures were collected by standardized protocols at T0 and T1.Results: Six variants of MMP3 gene were genotyped. Homozygotes for the variant A allele of rs646910 and for the H3 haplotype had higher hip circumference (P=0.002 and 0.001; age, sex and country adjusted) at T0. The association remained significant after false discovery rate (FDR) correction. At T1, subjects carrying rs646910 A/A genotype or H3/H3 diplotype showed significantly higher values of body mass index, waist and hip circumference and sum of tricipital and subscapular skinfolds, all associations remaining significant after FDR correction (P=0.020–0.048).Conclusions: We showed for the first time an association between the MMP3 rs646910 variant and indices of adiposity in European children, highlighting the involvement of metalloproteinase genes in adipose tissue remodeling and growth.",

keywords = "cardiovascular risk, children, matrix metalloproteinase, prospective study",

author = "D Cugino and F Gianfagna and W Ahrens and {De Henauw}, S and Koni, {A C} and S Marild and D Molnar and Moreno, {L A} and Y Pitsiladis and P Russo and A Siani and M Tornaritis and T Veidebaum and L Iacoviello",

note = "Publisher copyright: {\textcopyright} 2013 Macmillan Publishers Limited",

year = "2013",

month = dec,

doi = "10.1038/ijo.2013.21",

language = "English",

volume = "37",

pages = "1539--1544",

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Cugino, D, Gianfagna, F, Ahrens, W, De Henauw, S, Koni, AC, Marild, S, Molnar, D, Moreno, LA, Pitsiladis, Y, Russo, P, Siani, A, Tornaritis, M, Veidebaum, T & Iacoviello, L 2013, 'Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study', International Journal of Obesity, vol. 37, no. 12, pp. 1539-1544. https://doi.org/10.1038/ijo.2013.21

TY - JOUR

T1 - Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children

T2 - results of the IDEFICS study

AU - Cugino, D

AU - Gianfagna, F

AU - Ahrens, W

AU - De Henauw, S

AU - Koni, A C

AU - Marild, S

AU - Molnar, D

AU - Moreno, L A

AU - Pitsiladis, Y

AU - Russo, P

AU - Siani, A

AU - Tornaritis, M

AU - Veidebaum, T

AU - Iacoviello, L

PY - 2013/12

Y1 - 2013/12

N2 - Objective: We investigated the relationship between matrix metalloproteinase 3 (MMP3) polymorphisms and adiposity indices in European children of the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants) project.Subjects: A total of 16 224 Caucasian children (2–9 years) were recruited into a population-based survey from eight European countries. In all, 4540 children were randomly selected for genetic studies (T0); 3238 children were re-examined 2 years later (T1). Anthropometric measures were collected by standardized protocols at T0 and T1.Results: Six variants of MMP3 gene were genotyped. Homozygotes for the variant A allele of rs646910 and for the H3 haplotype had higher hip circumference (P=0.002 and 0.001; age, sex and country adjusted) at T0. The association remained significant after false discovery rate (FDR) correction. At T1, subjects carrying rs646910 A/A genotype or H3/H3 diplotype showed significantly higher values of body mass index, waist and hip circumference and sum of tricipital and subscapular skinfolds, all associations remaining significant after FDR correction (P=0.020–0.048).Conclusions: We showed for the first time an association between the MMP3 rs646910 variant and indices of adiposity in European children, highlighting the involvement of metalloproteinase genes in adipose tissue remodeling and growth.

AB - Objective: We investigated the relationship between matrix metalloproteinase 3 (MMP3) polymorphisms and adiposity indices in European children of the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants) project.Subjects: A total of 16 224 Caucasian children (2–9 years) were recruited into a population-based survey from eight European countries. In all, 4540 children were randomly selected for genetic studies (T0); 3238 children were re-examined 2 years later (T1). Anthropometric measures were collected by standardized protocols at T0 and T1.Results: Six variants of MMP3 gene were genotyped. Homozygotes for the variant A allele of rs646910 and for the H3 haplotype had higher hip circumference (P=0.002 and 0.001; age, sex and country adjusted) at T0. The association remained significant after false discovery rate (FDR) correction. At T1, subjects carrying rs646910 A/A genotype or H3/H3 diplotype showed significantly higher values of body mass index, waist and hip circumference and sum of tricipital and subscapular skinfolds, all associations remaining significant after FDR correction (P=0.020–0.048).Conclusions: We showed for the first time an association between the MMP3 rs646910 variant and indices of adiposity in European children, highlighting the involvement of metalloproteinase genes in adipose tissue remodeling and growth.

KW - cardiovascular risk

KW - children

KW - matrix metalloproteinase

KW - prospective study

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U2 - 10.1038/ijo.2013.21

DO - 10.1038/ijo.2013.21

M3 - Journal article

C2 - 23478427

AN - SCOPUS:84892574663

SN - 0307-0565

VL - 37

SP - 1539

EP - 1544

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 12

ER -

Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study

Abstract

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