Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng

Hongjie ZHANG, Zhizhen Lu, Ghee T. Tan, Shengxiang Qiu, Norman R. Farnsworth, John M. Pezzuto, Harry H.S. Fong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf, -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including 1D and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) with an IC50 value of 13.4 μg/mL (11.1 μM).

Original languageEnglish
Pages (from-to)973-977
Number of pages5
JournalTetrahedron Letters
Volume43
Issue number6
DOIs
Publication statusPublished - 4 Feb 2002

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Araliaceae
  • HIV
  • Panax ginseng
  • Polyacetyleneginsenoside

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