Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng

Hongjie Zhang; Zhizhen Lu; Ghee T. Tan; Shengxiang Qiu; Norman R. Farnsworth; John M. Pezzuto; Harry H.S. Fong

doi:10.1016/S0040-4039(01)02310-3

Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng

Hongjie Zhang
, Zhizhen Lu
, Ghee T. Tan
, Shengxiang Qiu
, Norman R. Farnsworth
, John M. Pezzuto
, Harry H.S. Fong^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

67 Citations (Scopus)

Abstract

A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf, -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including 1D and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) with an IC₅₀ value of 13.4 μg/mL (11.1 μM).

Original language	English
Pages (from-to)	973-977
Number of pages	5
Journal	Tetrahedron Letters
Volume	43
Issue number	6
DOIs	https://doi.org/10.1016/S0040-4039(01)02310-3
Publication status	Published - 4 Feb 2002

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Araliaceae
HIV
Panax ginseng
Polyacetyleneginsenoside

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10.1016/S0040-4039(01)02310-3

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title = "Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng",

abstract = "A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf, -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including 1D and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) with an IC50 value of 13.4 μg/mL (11.1 μM).",

keywords = "Araliaceae, HIV, Panax ginseng, Polyacetyleneginsenoside",

author = "Hongjie Zhang and Zhizhen Lu and Tan, \{Ghee T.\} and Shengxiang Qiu and Farnsworth, \{Norman R.\} and Pezzuto, \{John M.\} and Fong, \{Harry H.S.\}",

year = "2002",

month = feb,

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doi = "10.1016/S0040-4039(01)02310-3",

language = "English",

volume = "43",

pages = "973--977",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

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}

TY - JOUR

T1 - Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng

AU - Zhang, Hongjie

AU - Lu, Zhizhen

AU - Tan, Ghee T.

AU - Qiu, Shengxiang

AU - Farnsworth, Norman R.

AU - Pezzuto, John M.

AU - Fong, Harry H.S.

PY - 2002/2/4

Y1 - 2002/2/4

N2 - A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf, -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including 1D and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) with an IC50 value of 13.4 μg/mL (11.1 μM).

AB - A new oleanolic acid-derived saponin, polyacetyleneginsenoside-Ro (1), was isolated along with the known ginsenosides-Ro methyl ester (2), -Rf, -Rg1, -Rg2, and gingerglycolipid B from the roots of Panax ginseng C. A. Meyer. The new saponin was identified as a ginsenoside-Ro derivative containing a polyacetylene side chain by spectroscopic means including 1D and 2D NMR, and was found to inhibit the replication of human immunodeficiency virus type 1 (HIV-1) with an IC50 value of 13.4 μg/mL (11.1 μM).

KW - Araliaceae

KW - HIV

KW - Panax ginseng

KW - Polyacetyleneginsenoside

UR - https://www.scopus.com/pages/publications/0037016959

U2 - 10.1016/S0040-4039(01)02310-3

DO - 10.1016/S0040-4039(01)02310-3

M3 - Journal article

AN - SCOPUS:0037016959

SN - 0040-4039

VL - 43

SP - 973

EP - 977

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 6

ER -

Polyacetyleneginsenoside-Ro, a novel triterpene saponin from Panax ginseng

Abstract

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