Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells

Keyphrases

• Proliferation Apoptosis 100%
• Apoptosis Induction 100%
• Non-small Cell Lung Cancer Cells 100%
• Platycodin D 100%
• Proliferation Inhibition 100%
• AKT Inhibition 100%
• AKT Inhibitor 66%
• Non-small Cell Lung Cancer (NSCLC) 33%
• Small Interfering RNA (siRNA) 33%
• Antiproliferative Activity 33%
• Receptor Tyrosine Kinase 33%
• Human Epidermal Growth Factor Receptor 2 (HER2) 33%
• MK-2206 33%
• NSCLC Cells 33%
• Constitutively Active 16%
• Traditional Chinese Medicine 16%
• Cell Proliferation 16%
• Apoptotic Effect 16%
• AKT1 16%
• Monotherapy 16%
• Apoptotic Induction 16%
• Promising Target 16%
• Combined Method 16%
• Proliferative Inhibition 16%
• Co-treatment 16%
• Platycodonis Radix 16%
• Novel Combinations 16%
• Feedback Inhibition 16%
• Feedback Activation 16%
• 4E-BP1 16%

Biochemistry, Genetics and Molecular Biology

• Epidermal Growth Factor Receptor 100%
• Programmed Cell Death 100%
• Cancer Cell 100%
• Small Interfering RNA 100%
• Receptor Tyrosine Kinase 100%
• Cell Proliferation 50%
• Upregulation 50%
• Kinase 50%
• Phosphotransferase 50%
• Antiproliferative Activity 50%
• Product Inhibition 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Small Interfering RNA 100%
• Non Small Cell Lung Cancer 100%
• Epidermal Growth Factor Receptor 100%
• Protein Tyrosine Kinase 100%
• 8 [4 (1 Aminocyclobutyl)phenyl] 9 Phenyl 1,2,4 triazolo[3,4 f][1,6]naphthyridin 3(2h) One 100%
• Traditional Chinese Medicine 50%
• Phosphotransferase 50%
• Monotherapy 50%