Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats

Faith A. Bazley; Angelo H. All; Nitish V. Thakor; Anil Maybhate

doi:10.1109/IEMBS.2011.6090564

Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats

Faith A. Bazley^*
, Angelo H. All
, Nitish V. Thakor
, Anil Maybhate

^*Corresponding author for this work

Department of Chemistry

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

20 Citations (Scopus)

Abstract

Spinal cord injury (SCI) causes a number of physiological and neurological changes resulting in loss of sensorimotor function. Recent work has shown that the central nervous system is capable of plastic behaviors post-injury, including axonal regrowth and cortical remapping. Functional integrity of afferent sensory pathways can be quantified using cortical somatosensory evoked potentials (SSEPs) recorded upon peripheral limb stimulation. We implanted 15 rats with transcranial screw electrodes and recorded SSEPs from cortical regions corresponding to each limb before and after a mild or moderate contusion injury. We report a post-injury increase in the mean amplitude of cortical SSEPs upon forelimb stimulation. SSEP amplitudes for mild and moderate SCI groups increased by 183%95% and 107%38% over baseline, respectively, while hindlimb SSEPs decreased by 58%14% and 79%4%. In addition, we report increased SSEP amplitude measured from the anatomically adjacent hindlimb region upon forelimb stimulation (increase of 90%19%). Our results show that previously allocated hindlimb cortical regions are now activated by forelimb stimulation, suggesting an expansion in the area of cortical forelimb representation into hindlimb regions after an injury. This result is indicative of adaptive plasticity in undamaged areas of the CNS following SCI.

Original language	English
Title of host publication	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Place of Publication	Boston
Publisher	IEEE
Pages	2005-2008
Number of pages	4
ISBN (Electronic)	9781457715891, 9781424441228
ISBN (Print)	9781424441211
DOIs	https://doi.org/10.1109/IEMBS.2011.6090564
Publication status	Published - 30 Aug 2011
Event	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Boston, United States Duration: 30 Aug 2011 → 3 Sept 2011 https://ieeexplore.ieee.org/xpl/conhome/6067544/proceeding (Conference proceeding)

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1094-687X
ISSN (Electronic)	1558-4615

Conference

Conference	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated title	EMBS 2011
Country/Territory	United States
City	Boston
Period	30/08/11 → 3/09/11
Internet address	https://ieeexplore.ieee.org/xpl/conhome/6067544/proceeding (Conference proceeding)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1109/IEMBS.2011.6090564

Cite this

Bazley, F. A., All, A. H., Thakor, N. V., & Maybhate, A. (2011). Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (pp. 2005-2008). (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). IEEE. https://doi.org/10.1109/IEMBS.2011.6090564

Bazley, Faith A. ; All, Angelo H. ; Thakor, Nitish V. et al. / Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats. 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. Boston : IEEE, 2011. pp. 2005-2008 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats",

abstract = "Spinal cord injury (SCI) causes a number of physiological and neurological changes resulting in loss of sensorimotor function. Recent work has shown that the central nervous system is capable of plastic behaviors post-injury, including axonal regrowth and cortical remapping. Functional integrity of afferent sensory pathways can be quantified using cortical somatosensory evoked potentials (SSEPs) recorded upon peripheral limb stimulation. We implanted 15 rats with transcranial screw electrodes and recorded SSEPs from cortical regions corresponding to each limb before and after a mild or moderate contusion injury. We report a post-injury increase in the mean amplitude of cortical SSEPs upon forelimb stimulation. SSEP amplitudes for mild and moderate SCI groups increased by 183\%95\% and 107\%38\% over baseline, respectively, while hindlimb SSEPs decreased by 58\%14\% and 79\%4\%. In addition, we report increased SSEP amplitude measured from the anatomically adjacent hindlimb region upon forelimb stimulation (increase of 90\%19\%). Our results show that previously allocated hindlimb cortical regions are now activated by forelimb stimulation, suggesting an expansion in the area of cortical forelimb representation into hindlimb regions after an injury. This result is indicative of adaptive plasticity in undamaged areas of the CNS following SCI.",

author = "Bazley, \{Faith A.\} and All, \{Angelo H.\} and Thakor, \{Nitish V.\} and Anil Maybhate",

note = "This work was supported by the Maryland Stem Cell Research Fund under Grants 2007-MSCRFII-0159-00 and 2009-MSCRFII-0091-00 Publisher Copyright: {\textcopyright}2011 IEEE; 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 ; Conference date: 30-08-2011 Through 03-09-2011",

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Bazley, FA, All, AH, Thakor, NV & Maybhate, A 2011, Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, IEEE, Boston, pp. 2005-2008, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, Massachusetts, United States, 30/08/11. https://doi.org/10.1109/IEMBS.2011.6090564

Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats. / Bazley, Faith A.; All, Angelo H.; Thakor, Nitish V. et al.
33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. Boston: IEEE, 2011. p. 2005-2008 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

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T1 - Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats

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AU - All, Angelo H.

AU - Thakor, Nitish V.

AU - Maybhate, Anil

PY - 2011/8/30

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N2 - Spinal cord injury (SCI) causes a number of physiological and neurological changes resulting in loss of sensorimotor function. Recent work has shown that the central nervous system is capable of plastic behaviors post-injury, including axonal regrowth and cortical remapping. Functional integrity of afferent sensory pathways can be quantified using cortical somatosensory evoked potentials (SSEPs) recorded upon peripheral limb stimulation. We implanted 15 rats with transcranial screw electrodes and recorded SSEPs from cortical regions corresponding to each limb before and after a mild or moderate contusion injury. We report a post-injury increase in the mean amplitude of cortical SSEPs upon forelimb stimulation. SSEP amplitudes for mild and moderate SCI groups increased by 183%95% and 107%38% over baseline, respectively, while hindlimb SSEPs decreased by 58%14% and 79%4%. In addition, we report increased SSEP amplitude measured from the anatomically adjacent hindlimb region upon forelimb stimulation (increase of 90%19%). Our results show that previously allocated hindlimb cortical regions are now activated by forelimb stimulation, suggesting an expansion in the area of cortical forelimb representation into hindlimb regions after an injury. This result is indicative of adaptive plasticity in undamaged areas of the CNS following SCI.

AB - Spinal cord injury (SCI) causes a number of physiological and neurological changes resulting in loss of sensorimotor function. Recent work has shown that the central nervous system is capable of plastic behaviors post-injury, including axonal regrowth and cortical remapping. Functional integrity of afferent sensory pathways can be quantified using cortical somatosensory evoked potentials (SSEPs) recorded upon peripheral limb stimulation. We implanted 15 rats with transcranial screw electrodes and recorded SSEPs from cortical regions corresponding to each limb before and after a mild or moderate contusion injury. We report a post-injury increase in the mean amplitude of cortical SSEPs upon forelimb stimulation. SSEP amplitudes for mild and moderate SCI groups increased by 183%95% and 107%38% over baseline, respectively, while hindlimb SSEPs decreased by 58%14% and 79%4%. In addition, we report increased SSEP amplitude measured from the anatomically adjacent hindlimb region upon forelimb stimulation (increase of 90%19%). Our results show that previously allocated hindlimb cortical regions are now activated by forelimb stimulation, suggesting an expansion in the area of cortical forelimb representation into hindlimb regions after an injury. This result is indicative of adaptive plasticity in undamaged areas of the CNS following SCI.

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Bazley FA, All AH, Thakor NV, Maybhate A. Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats. In 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011. Boston: IEEE. 2011. p. 2005-2008. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/IEMBS.2011.6090564

Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats

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