Plasma metabolomics reveals biomarkers of the atherosclerosis

Xi Chen, Lian Liu, Gustavo Palacios, Jie Gao, Ning Zhang, Guang Li, Juan Lu, Ting Song, Yingzhi Zhang, Haitao Lv*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

69 Citations (Scopus)

Abstract

Atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in industrialized societies. The lack of metabolite biomarkers has impeded the clinical diagnosis of atherosclerosis so far. In this study, stable atherosclerosis patients (n516) and age- and sex-matched non-atherosclerosis healthy subjects (n528) were recruited from the local community (Harbin, P. R. China). The plasma was collected from each study subject and was subjected to metabolomics analysis by GC/MS. Pattern recognition analyses (principal components analysis, orthogonal partial least-squares discriminate analysis, and hierarchical clustering analysis) commonly demonstrated plasma metabolome, which was significantly different from atherosclerotic and nonatherosclerotic subjects. The development of atherosclerosis-induced metabolic perturbations of fatty acids, such as palmitate, stearate, and 1-monolinoleoylglycerol, was confirmed consistent with previous publication, showing that palmitate significantly contributes to atherosclerosis development via targeting apoptosis and inflammation pathways. Altogether, this study demonstrated that the development of atherosclerosis directly perturbed fatty acid metabolism, especially that of palmitate, which was confirmed as a phenotypic biomarker for clinical diagnosis of atherosclerosis.

Original languageEnglish
Pages (from-to)2776-2783
Number of pages8
JournalJournal of Separation Science
Volume33
Issue number17-18
Early online date20 Aug 2010
DOIs
Publication statusPublished - Sept 2010

Scopus Subject Areas

  • Analytical Chemistry
  • Filtration and Separation

User-Defined Keywords

  • Atherosclerosis
  • Biomarkers
  • GC/MS
  • Palmitate
  • Plasma metabolomics

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