Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases

Yaoyao Chang; Lixiang Zhai; Jiao Peng; Haiqiang Wu; Zhaoxiang Bian; Haitao Xiao

doi:10.1016/j.biopha.2021.111931

Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases

Yaoyao Chang, Lixiang Zhai, Jiao Peng, Haiqiang Wu, Zhaoxiang Bian, Haitao Xiao^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult to cure and characterized by periods of relapse. To face the challenges of limited treatment strategies and drawbacks of conventional medications, developing new and promising strategies as well as safe and effective drugs for treatment of IBD has become an urgent demand for clinics. The imbalance of Th17/Treg is a crucial event for the development of IBD, and studies have verified that correcting the imbalance of Th17/Treg is an effective strategy for preventing and treating IBD. Recently, a growing body of studies has indicated that phytochemicals derived from natural products are potent regulators of Th17/Treg, and exert preferable protective benefits against colonic inflammation. In this review, the great potential of anti-colitis agents derived from natural products through targeting Th17/Treg cells and their action mechanisms for the treatment or prevention of IBD in recent research is summarized, which may help further the development of new drugs for IBD treatment.

Original language	English
Article number	111931
Journal	Biomedicine and Pharmacotherapy
Volume	141
DOIs	https://doi.org/10.1016/j.biopha.2021.111931
Publication status	Published - Sept 2021

Scopus Subject Areas

Pharmacology

User-Defined Keywords

Inflammatory bowel disease (IBD)
Phytochemicals
Th17/Treg balance
Therapeutic effects
Action mechanism

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10.1016/j.biopha.2021.111931

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title = "Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases",

abstract = "Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult to cure and characterized by periods of relapse. To face the challenges of limited treatment strategies and drawbacks of conventional medications, developing new and promising strategies as well as safe and effective drugs for treatment of IBD has become an urgent demand for clinics. The imbalance of Th17/Treg is a crucial event for the development of IBD, and studies have verified that correcting the imbalance of Th17/Treg is an effective strategy for preventing and treating IBD. Recently, a growing body of studies has indicated that phytochemicals derived from natural products are potent regulators of Th17/Treg, and exert preferable protective benefits against colonic inflammation. In this review, the great potential of anti-colitis agents derived from natural products through targeting Th17/Treg cells and their action mechanisms for the treatment or prevention of IBD in recent research is summarized, which may help further the development of new drugs for IBD treatment.",

keywords = "Inflammatory bowel disease (IBD), Phytochemicals, Th17/Treg balance, Therapeutic effects, Action mechanism",

author = "Yaoyao Chang and Lixiang Zhai and Jiao Peng and Haiqiang Wu and Zhaoxiang Bian and Haitao Xiao",

note = "Funding Information: This work was kindly funded by the National Natural Science Foundation of China (81560676), SZU Top Ranking Project (86000000210) and Foundations of Shenzhen Science and Technology Innovation Committee (JCYJ20170413170320959), Medical Science and Technology Research Foundation of Guangdong Province, China (A2020157 and A2020272). Publisher Copyright: {\textcopyright} 2021 The Authors. Published by Elsevier Masson SAS.",

year = "2021",

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doi = "10.1016/j.biopha.2021.111931",

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AU - Chang, Yaoyao

AU - Zhai, Lixiang

AU - Peng, Jiao

AU - Wu, Haiqiang

AU - Bian, Zhaoxiang

AU - Xiao, Haitao

N1 - Funding Information: This work was kindly funded by the National Natural Science Foundation of China (81560676), SZU Top Ranking Project (86000000210) and Foundations of Shenzhen Science and Technology Innovation Committee (JCYJ20170413170320959), Medical Science and Technology Research Foundation of Guangdong Province, China (A2020157 and A2020272). Publisher Copyright: © 2021 The Authors. Published by Elsevier Masson SAS.

PY - 2021/9

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N2 - Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult to cure and characterized by periods of relapse. To face the challenges of limited treatment strategies and drawbacks of conventional medications, developing new and promising strategies as well as safe and effective drugs for treatment of IBD has become an urgent demand for clinics. The imbalance of Th17/Treg is a crucial event for the development of IBD, and studies have verified that correcting the imbalance of Th17/Treg is an effective strategy for preventing and treating IBD. Recently, a growing body of studies has indicated that phytochemicals derived from natural products are potent regulators of Th17/Treg, and exert preferable protective benefits against colonic inflammation. In this review, the great potential of anti-colitis agents derived from natural products through targeting Th17/Treg cells and their action mechanisms for the treatment or prevention of IBD in recent research is summarized, which may help further the development of new drugs for IBD treatment.

AB - Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult to cure and characterized by periods of relapse. To face the challenges of limited treatment strategies and drawbacks of conventional medications, developing new and promising strategies as well as safe and effective drugs for treatment of IBD has become an urgent demand for clinics. The imbalance of Th17/Treg is a crucial event for the development of IBD, and studies have verified that correcting the imbalance of Th17/Treg is an effective strategy for preventing and treating IBD. Recently, a growing body of studies has indicated that phytochemicals derived from natural products are potent regulators of Th17/Treg, and exert preferable protective benefits against colonic inflammation. In this review, the great potential of anti-colitis agents derived from natural products through targeting Th17/Treg cells and their action mechanisms for the treatment or prevention of IBD in recent research is summarized, which may help further the development of new drugs for IBD treatment.

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Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases

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