Physiological effects of microgravity on bone cells

Yasir Arfat, Wei Zhong Xiao, Salman Iftikhar, Fan Zhao, Di Jie Li, Yu Long Sun, Ge ZHANG, Peng Shang, Ai Rong Qian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Life on Earth developed under the influence of normal gravity (1g). With evidence from previous studies, scientists have suggested that normal physiological processes, such as the functional integrity of muscles and bone mass, can be affected by microgravity during spaceflight. During the life span, bone not only develops as a structure designed specifically for mechanical tasks but also adapts for efficiency. The lack of weight-bearing forces makes microgravity an ideal physical stimulus to evaluate bone cell responses. One of the most serious problems induced by long-term weightlessness is bone mineral loss. Results from in vitro studies that entailed the use of bone cells in spaceflights showed modification in cell attachment structures and cytoskeletal reorganization, which may be involved in bone loss. Humans exposed to microgravity conditions experience various physiological changes, including loss of bone mass, muscle deterioration, and immunodeficiency. In vitro models can be used to extract valuable information about changes in mechanical stress to ultimately identify the different pathways of mechanotransduction in bone cells. Despite many in vivo and in vitro studies under both real microgravity and simulated conditions, the mechanism of bone loss is still not well defined. The objective of this review is to summarize the recent research on bone cells under microgravity conditions based on advances in the field.

Original languageEnglish
Pages (from-to)569-579
Number of pages11
JournalCalcified Tissue International
Volume94
Issue number6
DOIs
Publication statusPublished - Jun 2014

Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

User-Defined Keywords

  • Bone cell
  • Bone loss
  • Mechanotransduction
  • Microgravity
  • Physiological effect
  • Simulated microgravity

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