Phylogenetic Comparison and Splicing Analysis of the U1 snRNP-specific Protein U1C in Eukaryotes

Kai Lu Zhang, Jian Li Zhou, Jing Fang Yang, Yu Zhen Zhao, Debatosh Das, Ge Fei Hao, Caie Wu, Jianhua Zhang, Fu Yuan Zhu, Mo Xian Chen, Shao Ming Zhou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

As a pivotal regulator of 5’ splice site recognition, U1 small nuclear ribonucleoprotein (U1 snRNP)-specific protein C (U1C) regulates pre-mRNA splicing by interacting with other components of the U1 snRNP complex. Previous studies have shown that U1 snRNP and its components are linked to a variety of diseases, including cancer. However, the phylogenetic relationships and expression profiles of U1C have not been studied systematically. To this end, we identified a total of 110 animal U1C genes and compared them to homologues from yeast and plants. Bioinformatics analysis shows that the structure and function of U1C proteins is relatively conserved and is found in multiple copies in a few members of the U1C gene family. Furthermore, the expression patterns reveal that U1Cs have potential roles in cancer progression and human development. In summary, our study presents a comprehensive overview of the animal U1C gene family, which can provide fundamental data and potential cues for further research in deciphering the molecular function of this splicing regulator.

Original languageEnglish
Article number696319
Number of pages13
JournalFrontiers in Molecular Biosciences
Volume8
DOIs
Publication statusPublished - 9 Sep 2021

Scopus Subject Areas

  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Biology

User-Defined Keywords

  • alternative splicing
  • gene expression
  • phylogenetics
  • splice site
  • U1-snRNP

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